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Part I. Chronic Leukemias and Related Disorders: 1. A history of the chronic leukemias; 2. Epidemiology of the chronic leukemias; 3. Pathology and morphology of chronic leukemias and related disorders; 4. Molecular biology and cytogenetics of chronic myeloid leukemia; 5. Diagnosis and treatment of chronic myeloid leukemia; 6. Molecular biology and cytogenetics of chronic lymphocytic leukemia; 7. Diagnosis and treatment of chronic lymphocytic leukemia; 8. Diagnosis and treatment of hairy cell leukemia; 9. The pathogenesis, diagnosis and treatment of polycythaemia vera; 10. Diagnosis and treatment of essential thrombocythemia and chronic idiopathic myelofibrosis; Part II. Acute Leukemias: 11. Historical perspectives; 12. Human t-cell lymphoma/leukemia virus associated t-cell lymphoma and leukemia; 13. Epidemiology and hereditary aspects of acute leukemia; 14. Classification of the acute leukemias: cytochemical and morphologic considerations; 15. Immunobiology of acute leukemia; 16. Cytogenetics of acute leukemia; 17. Diagnosis and treatment of childhood acute lymphoblastic leukemia; 18. Diagnosis and treatment of adult acute lymphoblastic leukemia; 19. Diagnosis and treatment of childhood acute myelogenous leukemia; 20. Diagnosis and treatment of adult acute myeloid leukemia other than acute promyelocytic leukemia; 21. Acute promyelocytic leukemia; 22. Therapy-related acute myelogenous leukemia; 23. Myelodysplastic syndromes; Part III. Myeloma and Related Disorders: 24. History of multiple myeloma; 25. Cytokines and signal transduction in multiple myeloma; 26. Epidemiology of multiple myeloma; 27. Immunoglobins and laboratory recognition of monoclonal proteins; 28. Cytogenetic abnormalities in the monoclonal gammopathies; 29. Molecular genetics in multiple myeloma and related disorders; 30. Staging, kinetics and prognosis in multiple myeloma; 31. Diagnosis and treatment of multiple myeloma; 32. Syndromes and special presentations associated with plasma cell myeloma; 33. Waldenstrom's macroglobulinemias; 34. Heavy-chain disease; 35. Amyloidosis; 36. Monoclonal gammopathies of undetermined significance; Part IV. Lymphoma: 37. Historical overview of malignant lymphoma; 38. Etiology of lymphoma and Hodgkin's disease; 39. Epidemiology and hereditary aspects of malignant lymphoma and Hodgkin's disease; 40. Pathology of non-Hodgkin's lymphomas and Hodgkin's disease; 41. Immunology of the lymphomas; 42. Cytogenetics of non-Hodgkin lymphoma and Hodgkin disease; 43. Diagnosis and treatment of Hodgkin's disease; 44. Radiotherapeutic management of lymphomas; 45. Diagnosis and treatment of non-Hodgkin's lymphoma of adults; 46. Non-Hodgkin's lymphoma of childhood; 47. Lymphoma in other diseases; Part V. Supportive Care: 48. Historical perspectives; 49. Prevention of infection in patients with hematological malignancies; 50. Evaluation and management of bacterial and fungal infections occurring in patients with hematological malignancy; 51. Viral infections in patients with hematological malignancies; 52. Therapeutic cytapheresis and plasma exchange; 53. Red cell transfusions in patients with hematologic malignancies; 54. Platelet and granulocyte transfusion; 55. Stem cell processing and purging; 56. Alternative sources of hemopoietic stem cells and their clinical applications; 57. Umbilical cord stem cell transplantation; 58. HLA typing in hematopoietic cell transplantation; 59. Special care of blood and marrow stem cell transplant patients; 60. Hematopoietic growth factors in the supportive care and treatment of patients with hematologic malignancies; 61. Bleeding and thrombosis in hematologic neoplasia; 62. Psychological aspects of hematological malignancies.

xv, 1196 pages, 12 unnumbered pages of plates : illustrations (some color) ; 29 cm

In this fourth edition of the classic work on malignant blood cancers, the team of editors and over 100 international leaders in the field provide a comprehensive text on the diagnosis and treatment of all hematologic malignancies, both common and rare. This extensively revised and updated edition reflects the tremendous progress in the science and treatment of hematologic malignancies during the eight years since the third edition. Revisions and new chapters include coverage of stem cell transplantation, molecular genetics, monoclonal antibodies, and new treatment modalities

Neoplastic diseases of the blood