Ibuprofen: A Critical Bibliographic ReviewKim D. Rainsford CRC Press, 2 sept 2003 - 595 páginas Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data. |
Índice
1 History and Development of Ibuprofen | 1 |
2 The Medicinal Chemistry of Ibuprofen | 23 |
3 The Pharmaceutics of Ibuprofen | 48 |
4 The Pharmacokinetics of Ibuprofen in Humans and Animals | 79 |
5 Pharmacology and Toxicology of Ibuprofen | 132 |
6 Therapeutics of Ibuprofen in Rheumatic and Other Chronic and Painful Diseases | 254 |
7 Safety and Efficacy of NonPrescription OTC Ibuprofen | 324 |
8 Use of Ibuprofen in Dentistry | 377 |
9 Gastrointestinal Adverse Drug Reactions Attribute to Ibuprofen | 398 |
10 Renal Effects of Ibuprofen | 424 |
Effects Other Than Gastrointestinal | 458 |
12 Human Toxicity of Ibuprofen | 497 |
Appedix I Some Brands of Ibuprofen in Various Countries | 516 |
Appendix II Methods for Analysis of Ibuprofen in Biological Systems | 523 |
| 528 | |
Otras ediciones - Ver todo
Ibuprofen: A Critical Bibliographic Review Kim D. Rainsford No hay ninguna vista previa disponible - 2019 |
Ibuprofen: A Critical Bibliographic Review Kim D. Rainsford No hay ninguna vista previa disponible - 1999 |
Términos y frases comunes
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Pasajes populares
Página 561 - Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System.
Página 538 - Roujeau JC, Kelly JP, Naldi L, et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med.