Stress-Inducible Cellular ResponsesU. Feige, R.I. Morimoto, Barbara Polla Springer Science & Business Media, 26 sept 1996 - 495 páginas This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimental approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. |
Índice
Introduction | 2 |
Normal protein folding machinery | 3 |
Roles for hsp70 in protein translocation across membranes of organelles | 25 |
Protein folding and assembly in the endoplasmic reticulum | 41 |
Involvement of molecular chaperones in intracellular protein breakdown | 57 |
Molecular chaperoning of steroid hormone receptors | 79 |
A multifunctional protein of the endoplasmic reticulum | 97 |
Introduction | 120 |
Mammalian DNA repair responses and genomic instability | 289 |
Toxic metalresponsive gene transcription | 307 |
Protection against oxidative stress through induction of MnSOD | 321 |
Introduction | 336 |
Viral infection | 337 |
Infection autoimmunity and autoimmune disease | 359 |
Stress proteins in inflammation | 375 |
Molecular mechanism and implication in the biology of aging | 393 |
Sensing stress and responding to stress | 121 |
A plethora of heat shock factors and regulatory conditions | 139 |
Transcriptional regulation of stressinducible genes in procaryotes | 165 |
The impact of oxidative stress on eukaryotic iron metabolism | 183 |
Heatshock induced protein modifications and modulation of enzyme activities | 199 |
SOS response as an adaptive response to DNA damage in prokaryotes | 221 |
Introduction | 238 |
Transcriptional regulators of oxidative stressinducible genes in prokaryotes and eukaryotes | 239 |
UV activation of mammalian stress proteins | 255 |
Signaling events controlling the molecular response to genotoxic stress | 273 |
Introduction | 410 |
Stress proteins as molecular biomarkers for environmental toxicology | 411 |
Possible involvement of Ku autoantigen in regulating Hsp70 expression | 425 |
Heat shock proteins as immunological carriers and vaccines | 451 |
Regulation of thermotolerance and ischemic tolerance | 467 |
Future applications | 483 |
Outlook | 485 |
489 | |
Otras ediciones - Ver todo
Stress-Inducible Cellular Responses U. Feige,R.I. Morimoto,Barbara Polla Vista previa restringida - 2013 |
Stress-Inducible Cellular Responses U. Feige,R.I. Morimoto,Barbara Polla No hay ninguna vista previa disponible - 2011 |
Stress-Inducible Cellular Responses U. Feige,R. I. Morimoto,Barbara Polla No hay ninguna vista previa disponible - 2014 |
Términos y frases comunes
Acad aconitase antigen apoptosis autoimmune disease Biochem Biol biomarkers calnexin cell lines cellular Chem complex cytosolic degradation DNA binding DNA damage DNA repair DnaJ DnaK domain EMBO encoding enzyme Escherichia coli eukaryotic function gene expression GroEL GrpE heat shock factor heat shock genes heat shock protein heat shock response heat shock transcription homologous HSF1 hsp70 gene hsp70 proteins human hsp70 immune increased induced infection inhibition interaction involved levels mammalian cells MAP kinase mechanism mediated membrane mitochondrial MnSOD molecular chaperones mRNA mutant Natl overexpression oxidative stress pathway peptide phosphorylation Polla polymerase polypeptides Proc promoter protease protective protein disulfide isomerase protein folding protein kinase protein synthesis quercetin radiation RecA receptor regulation regulatory replication role sequence signal specific stress proteins stress response studies substrate subunit temperature thermotolerance tion transcription factor transcriptional activation translocation tumor necrosis ubiquitination virus vitro vivo yeast
Pasajes populares
Página 480 - DM (1993) Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88, 1264-1272.