Stress-Inducible Cellular Responses

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U. Feige, R.I. Morimoto, Barbara Polla
Springer Science & Business Media, 26 sep. 1996 - 495 páginas
This book will deal with heat shock proteins and more generally with stress related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimental approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The book considers heat shock from a broad perspective including fields for which heat-shock may become important in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. All those working on stress and every participant in a 'stress laboratory' will find this book to be invaluable as a source of knowledge and perspectives. Series: Experientia Supplementum, Volume 77 Contents: Foreword Introduction -I.Yahara Part I Functions of stress proteins in unstressed cells Introduction -I. Yahara Normal protein folding machinery -D.Hartman and M.-J. Gething Roles for hsp70 in protein translocation across membranes of organelles -D.M. Cyr and W. Neupert Protein folding and assembly in the endoplasmic reticulum -J. Wei and L.M. Hendershot Involvement of molecular chaperones in intracellular protein breakdown -M. Sherman and A.L. Goldberg Molecular chaperoning of steroid hormone receptors -W.B. Pratt, U. Gehring, and D.O. Taft Protein disulfide isomerase: A multifunctional protein of the endoplasmic reticulum J.M. Luz and W.J. Lennarz Part II: Regulation of inducible stress responses Introduction -R.I.Morimoto Sensing stress and responding to stress -R. Voellmy The transcriptional regulation of heat shock genes: A plethora of heat shock factors and regulatory conditions -R.I. Morimoto, P.E. Kroeger, and J.J. Cotto Transcriptional regulation of stress-inducible genes in procaryotes -T. Yura, K. Nagahigashi, and M. Kanemori The impact of oxidative stress on eukaryotic iron metabolism -T.A.Rouault and R.D. Klausner Heat-shock induced protein modifications and modulation of enzyme activities -O. Bensaude, S. Bellier, M.-F. Dubois, F. Giannoni, and V.T. Nguyen SOS response as an adaptive response to DNA damage in prokaryotes H. Shinagawa Part III: Cellular responses to specific stresses Introduction -B.S. Polla Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukayotes -G. Storz and B.S. Polla UV activation of mammalian stress proteins -R.M. Tyrrell Signaling events controlling the molecular response to to genotoxic stress -N.J. Holbrook, Y. Liu, and A.J. Fornace, Jr. Mammalian DNA repair responses and geomic instability -C.M.J. ap Rhys and V.A. Bohr Toxic metal-responsive gene transcription -Z. Zhu and D.J. Thiele Tumor necrosis factor and lymphotoxin: Protection against oxidative stress through induction of MnSOD - G.H.W. Wong, R.L. Kaspar, and G. Vehar Part IV: Paradigms for complex stress responses Introduction -U. Feige Viral infection -M.G. Santoro Infection, autoimmunity, and autoimmune disease -U. Feige and W. van Eden Stress proteins in inflammation -B.S. Polla and A. Cossarizza Attenuated heat shock transcriptional response in aging: Molecular mechanism and implication in the biology of aging -A.Y.-C. Liu, Y.-K. Lee, D. Manalo, and L.E. Huang Part V: Applications of stress responses in toxicology and pharmacology Introduction -I. Yahara Stress proteins as molecular biomarkers for environmental toxicology -J.A. Ryan and L.E. Hightower Thermotolerance and heat shock proteins: Possible involvement of Ku autoantigen in regulating HSP70 expression -G.C. Li and A. Nussenzweig Heat shock proteins as immunological carriers and vaccines -K. Suzue and R.A. Young Regulation of thermotolerance and ischemic tolerance -K. Nagata Future applications -B.S. Polla Outlook -R.I. Morimoto Subject index
 

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Índice

Introduction
2
Normal protein folding machinery
3
Roles for hsp70 in protein translocation across membranes of organelles
25
Protein folding and assembly in the endoplasmic reticulum
41
Involvement of molecular chaperones in intracellular protein breakdown
57
Molecular chaperoning of steroid hormone receptors
79
A multifunctional protein of the endoplasmic reticulum
97
Introduction
120
Mammalian DNA repair responses and genomic instability
289
Toxic metalresponsive gene transcription
307
Protection against oxidative stress through induction of MnSOD
321
Introduction
336
Viral infection
337
Infection autoimmunity and autoimmune disease
359
Stress proteins in inflammation
375
Molecular mechanism and implication in the biology of aging
393

Sensing stress and responding to stress
121
A plethora of heat shock factors and regulatory conditions
139
Transcriptional regulation of stressinducible genes in procaryotes
165
The impact of oxidative stress on eukaryotic iron metabolism
183
Heatshock induced protein modifications and modulation of enzyme activities
199
SOS response as an adaptive response to DNA damage in prokaryotes
221
Introduction
238
Transcriptional regulators of oxidative stressinducible genes in prokaryotes and eukaryotes
239
UV activation of mammalian stress proteins
255
Signaling events controlling the molecular response to genotoxic stress
273
Introduction
410
Stress proteins as molecular biomarkers for environmental toxicology
411
Possible involvement of Ku autoantigen in regulating Hsp70 expression
425
Heat shock proteins as immunological carriers and vaccines
451
Regulation of thermotolerance and ischemic tolerance
467
Future applications
483
Outlook
485
Subject Index
489
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Página 480 - DM (1993) Cardiac stress protein elevation 24 hours after brief ischemia or heat stress is associated with resistance to myocardial infarction. Circulation 88, 1264-1272.

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