A Guide to Phospholipid ChemistryOxford University Press, 1 may 1997 - 224 páginas This book provides a concise introduction to phospholipid chemistry and is intended for a broad audience of biologists, biochemists, and graduate students. Developed as part of a graduate course on lipids, this book also serves as a reference for laboratory investigators on signal transduction and biological membranes. The first part of the text is devoted to an orientation to the chemical nature of lipids in general, how they are thought to be associated in the cell, and the methodology by which the cellular lipids (including the phospholipids) can be recovered from cells and subjected to an initial identification. Subsequent chapters characterize the choline-containing phospholipids, including the sphingolipids, the non-choline containing phospholipids, and finally, the so-called minor phospholipids. The latter compounds, which act as agonists or lipid chemical mediators on cells, form a vanguard of a new category of biologically active substances and have set the study of cellular phospholipids on a new and exiting course. Most importantly, this book provides a basis for further inquiry on these complicated molecules, showing that although the compounds are unique, with care and understanding, they can be studied with ease |
Índice
3 | |
Phospholipids Associations in Cellular Structures | 25 |
Isolation and Identification of Cellular Phospholipids | 39 |
CholineContaining Phospholipids Diacyl Alkylacyl and Alkenylacylcholine Phosphoglycerides and Sphingomyelin | 61 |
NonCholineContaining Phospholipids Diacyl Alkylacyl AlkenylacylEthanolaminephosphoglycerides Phosphatidylinositols and Phosphatidylserine | 131 |
Minor Phospholipids Platelet activating factor PAF and PAF analogs Lysophosphatidic acid and phosphatidic acid Phosphatidylglycerol Cardiolipin S... | 165 |
195 | |
208 | |
Otras ediciones - Ver todo
Términos y frases comunes
agonist alkenylacyl alkyl alkylacyl amounts analyzed approach assay biological activity bond cardiolipin cellular Chapter chloroform chloroform-methanol chloroform-methanol-water chloroform-rich choline choline-containing cleavage column components compounds containing derivative described earlier detected diacyl diacylglycerol diethyl ether diglyceride elution enzyme ester ethanolamine experimental FAB-MS fatty acids fatty acyl Figure fraction gel G glycerides glycerol glyceryl ether Hanahan HPLC human platelets identification important inositol interaction isolated latter lipid extract long-chain fatty mammalian cells mass spectrometry membrane methanol methanolysis methodology methyl esters mixture molecule naturally occurring neutral nitrogen optical activity oxidation phos phosphate phosphatidic acid phosphatidylcholine phosphatidylethanolamine phosphatidylglycerol phosphatidylinositol phosphatidylserine phospho phosphoglycerides phospholipase A2 phospholipids phosphorus plate present procedure protein purification quantitative reaction reagent residue room temperature separation serine signal transduction silica gel sn-3 configuration solvent system specific sphingomyelin sphingosine spray structure proof substrate synthetic technique thin-layer chromatography tion tissue total lipid unsaturated vinyl ether yield
Pasajes populares
Página 203 - DEVANE, WA, HANUS, L., BREUER, A., PERTWEE, RG, STEVENSON, LA, GRIFFIN, G., GIBSON, D., MANDELBAUM, A., ETINGER, A.
Página 204 - Y. ( 1979) Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem. Biophys. Res. Commun., 91.
Página 203 - Separation of phospholipids by high performance liquid chromatography : all major classes, including ethanolamine and choline plasmalogens, and most minor classes, including lysophosphatidylethanolamine.
Página 205 - Haverkate F. and Van Deenen LLM, 1965. — Isolation and chemical characterization of phosphatidylglycerol from spinach leaves.
Página 204 - Stephens, LR, Hughes, KT, and Irvine, RF (1991) Pathway of phosphatidylinositol (3,4,5)-trisphosphate synthesis in activated neutrophils, Nature 351, 33-39. Stephens, LR, Jackson, TR, and Hawkins, PT (1993) Agonist-stimulated synthesis of phosphatidyl inositol (3,4,5)-trisphosphate: a new intracellular signalling system?
Página 204 - Streb, H., Irvine, RF, Berridge, MJ, and Schulz, I. (1983). Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol- 1,4,5-trisphosphate.
Referencias a este libro
Magnetic Resonance in Food Science: The Multivariate Challenge P. S. Belton,Søren Balling Engelsen,Hans Jørgen Jakobsen Vista previa restringida - 2005 |
Encyclopedia of Surface and Colloid Science, Volumen 5 P. Somasundaran Vista previa restringida - 2006 |