Redox-Genome Interactions in Health and Disease

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Jörgen Fuchs, Maurizio Podda, Lester Packer
CRC Press, 12 sept 2003 - 640 páginas
At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.
 

Índice

RedoxGenome Interactions Evolution of a Concept
1
Measurements of Biological Reducing Power by Voltammetric Methods
13
Composition and Regulation of ThiolDisulfide Redox State
43
Thiols and Thioredoxin in Cellular Redox Control
61
Role of Free Radicals and Cellular Redox Status in Signal Transduction and Gene Expression
79
Redox Regulation of Apoptosis
101
Mitochondria Aging and Disease A Genomic Perspective
123
The Human Genome as a Target of Oxidative Modification Damage to Nucleic Acids
145
Association of Oxidative Stress with Cataractogenesis
325
Oxidative Stress and AgeRelated Macular Degeneration
351
Retinitis Pigmentosa A Potential Role for Reactive Oxygen and Nitrogen Species During Photoreceptor Apoptosis
377
The Role of Oxidative Imbalance in the Pathogenesis of Down Syndrome
409
Metal Homeostasis and Its Relation to Oxidative Stress in Alzheimers Disease
425
Oxidative Stress and Huntingtons Disease
439
Oxidative Stress in Familial Amyotrophic Lateral Sclerosis
473
Oxidants and Antioxidants in the Pathology of Colon Cancer
497

Redox Modulation in Tumor Initiation Promotion and Progression
193
The Potential Impact of Polymorphism on Oxidative Stress Status
217
Mitochondrial Dysfunction in Genetic Diseases
235
Oxidative and Nitrosative Stress in Cystic Fibrosis Significance or Triviality?
263
Oxyradicals in Iron Overload Syndromes Hemochromatosis
287
Oxidative Imbalance in Hereditary Hemoglobinopathies The Role of Reactive Oxygen Species in the Pathophysiology of Sickle Cell Anemia and Tha...
305
The Role of Oxidative Imbalance in Diabetes Mellitus
513
The Role of Reactive Oxygen Species the ReninAngiotensin System and Endothelin in the Development of Essential Hypertension
541
Oxidative Stress in Cardiovascular Disease Role of Oxidized Lipoproteins in Macrophage Foam Cell Formation and Atherosclerosis
557
Free Radicals in Rheumatoid Arthritis Mediators and Modulators
591
Index
611
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