Mechanisms of Invasion and MetastasisCRC Press, 23 abr 1991 - 584 páginas This book covers important biological, immunological, and molecular information essential for understanding the rationale and results of experiments and clinical observations on cell-cell and cell substrate adhesion; hydrolytic activities, cell motility; immunological and other host elements of the host-tumor ecosystem (at different sites of the metastic process); genetic and epigenetic elements of the acquisition and the expression of invasive phenotypes. 38 tables and 60 computer-drawn figures provide comprehensive overviews, and a methodological chapter emphasizing the differences and similarities between assays and their relevance for natural situations has also been included. Clinical and experimental cancer researchers, as well as as post-graduate students interested in cancer research, will find this book to be an indispensable reference resource. |
Índice
Introduction | 1 |
Chapter V | 3 |
Chapter II | 7 |
C | 13 |
D | 22 |
3 | 30 |
Chapter III | 41 |
C | 45 |
B HostTumor Interactions in the Circulation | 234 |
HostTumor Interactions at Secondary Sites | 245 |
Summary and Concluding Remarks | 251 |
Chapter VI | 267 |
B Regulatory Genes for Invasion and Metastasis | 282 |
Pleiotropic Effects as Elements of Invasion and Metastasis | 341 |
Summary and Concluding Remarks | 379 |
Chapter VII | 419 |
C | 51 |
References | 73 |
d | 82 |
CellSubstrate Interactions as Elements of Malignancy | 98 |
Hydrolase Activities as Elements of Malignancy | 127 |
Motility and Migration as Elements of Malignancy | 158 |
E Evaluation and Summary | 174 |
Contributions of the Host to Invasion and Metastasis | 221 |
Aspecific Lymphocyte Effector Cells | 445 |
Myeloid Immune Effector Cells | 458 |
Tools | 487 |
References | 525 |
Chapter IX | 545 |
562 | |
Términos y frases comunes
acid adhesion molecules antibodies antigen assays B16 melanoma basement membrane binding breast c-Ha-ras Cancer Inst Cancer Metastasis Cancer Res carcinoma cells cell adhesion Cell Biol cell lines cell surface cell types cell-cell adhesion cellular chemotaxis Clin clones CNaseIV collagenase colon correlation culture cytokines differentiation domain endothelial cells epithelial cells experimental expression extracellular fibroblasts fibronectin fibrosarcoma Figure function gene glycoprotein growth factor host human tumor hydrolases immune Immunol increased induced inhibition inhibitor integrin interactions interleukin invasion and metastasis laminin lesions leukocytes liver lung lymphocytes lymphoma M+ phenotypes macrophages malignant mammary Mareel matrix melanoma melanoma cells metastasis metastatic metastatic potential Mexp mice migration motility mouse Mspo murine Natl normal oncogene phenotype plasminogen activator platelet primary tumor protease protein proteoglycans receptor reviewed in References role sarcoma secreted Section specific substrate tenascin TGF-B tissue transfection tumor cells tumorigenic type IV collagen variants vitro vivo
Referencias a este libro
Brain Tumor Invasion: Biological, Clinical, and Therapeutic Considerations Tom Mikkelsen Vista de fragmentos - 1998 |
Metastasis: Basic Research and Its Clinical Applications H. Rabes,P. E. Peters,Klaus Munk Vista de fragmentos - 1992 |