Anti-AIDS Drug DevelopmentCRC Press, 1 mar 1995 - 304 páginas Curative anti-AIDS drug therapy still remains as an unconquered hurdle to drug research. This book covers significant aspects that are involved in the search, design and development of potential anti-AIDS agents with emphasis on areas related to drug development. These include enzyme inhibitors (reverse transcriptase, protease, glucosidase), inhibitors of gene expression (oligonucleotides), viral-binding inhibitors (anionic compounds and CD4 mimetics) and various plant derived products. A focus of this book is the medicinal chemistry of these classes of compounds. In addition, other areas that are pertinent to drug development are also addressed. These include HIV regulatory proteins, the development of anti-HIV-1 assays and resistance to anti-HIV-1 agents. |
Índice
Nucleosides and Derivatives | 39 |
65 | 46 |
Iminosugar aGlucosidase Inhibitors | 91 |
Regulatory Proteins of Human Immunodeficiency | 117 |
CD4 Mimetics and Analogs | 139 |
Resistance to AntiHIV Agents for AntiAIDS Drug Development | 163 |
Significance and Limitations | 185 |
Plantderived AntiHIV Agents | 211 |
HIV1specific Reverse Transcriptase Inhibitors | 255 |
Small and Large Polyanionic Derivatives | 269 |
Index | 276 |
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Términos y frases comunes
Acad Agents Chemother AIDS analogues anti-HIV activity anti-HIV agents Antimicrob antiretroviral antisense oligonucleotides antiviral activity antiviral agents assay ATH8 Baba Balzarini binding Biochem Broder Bu-DNJ castanospermine CD4+ cellular Chem Clercq clinical compounds concentration cytotoxicity dideoxynucleoside drug envelope glycoprotein enzyme gene glycoprotein glycosylation HEPT HIV infection HIV PR HIV protease HIV replication HIV-1 reverse transcriptase HIV-1 RT HIV-1-specific human immunodeficiency virus immunodeficiency virus type infected cells inhibit HIV inhibition of human inhibitor of HIV-1 inhibitory effect interaction isolates Mitsuya molecular molecule mutation Natl nevirapine nucleoside oligosaccharides patients Pauwels pharmacokinetic Pharmacol phosphorothioate phosphorylation polymerase potent and selective potent inhibitors Proc protease inhibitors protein residues resistance reverse transcriptase inhibitors Richman RNase H RT inhibitors S-oligonucleotides Schinazi Schols specific structure sulfonic acid suramin susceptibility syncytium syncytium formation synthesis T-cell target cells therapy toxicity V3 loop viral Virol virus replication vitro vivo zidovudine µg/ml