DNA Repair and MutagenesisASM Press, 1995 - 698 páginas DNA Repair and Mutagenesis is an extremely comprehensive and current text covering the manifold ways in which living cells respond to genomic injury and alterations, including both spontaneous and environmentally induced DNA damage. This book begins with a discussion of the phenomena of DNA damage and mutagenesis and then systematically explores all of the known DNA repair and other cellular response modes in prokaryotes and eukaryotes, including mammalian cells. A major feature of this edition is the comprehensive coverage of mutagenesis and other aspects of DNA damage tolerance. The final chapter is devoted to a discussion of known human diseases and disease syndromes with defective cellular responses to DNA damage. |
Índice
Introduction to Mutagenesis | 59 |
DNA Repair by Reversal of Damage | 91 |
Base Excision Repair | 135 |
Página de créditos | |
Otras 11 secciones no se muestran.
Otras ediciones - Ver todo
DNA Repair and Mutagenesis Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood Vista previa restringida - 2005 |
Términos y frases comunes
Acad activity Adapted adducts alleles amino acid AP endonuclease Bacteriol base damage binding Biochem Biol cell lines chapter Chem chromosome cleavage cloned complex defective deletion DNA damage DNA glycosylase DNA ligase DNA photolyase DNA polymerase DNA polymerase III DNA repair DNA replication DNA synthesis double-strand breaks E. C. Friedberg encodes enzyme Escherichia coli eukaryotic function Genet genome helicase heteroduplex homologous human cells incision induced inhibition irradiation lesions LexA mammalian cells mechanism methyl mismatch repair molecular molecules mutagenesis mutagenic mutations Natl Nature London Nucleic Acids Res nucleotide excision repair observed phage phenotype photolyase photoproducts plasmid polypeptide Proc protein purified pyrimidine dimers RAD2 Rad3 reaction RecA RecA protein recombination region repair gene repair synthesis repressor residues role Saccharomyces cerevisiae Sancar sensitive specific strains strand breaks substrate thymine transcription ultraviolet UmuD UV radiation UV-irradiated UvrA protein UvrB vitro vivo wild-type xeroderma pigmentosum yeast