Asthma: Basic Mechanisms and Clinical ManagementNow available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field.
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Índice
11 | |
17 | |
35 | |
47 | |
53 | |
59 | |
65 | |
Effects of posture and sleep on airway function | 76 |
References | 471 |
Extracellular matrix | 478 |
References | 484 |
Structural cells | 491 |
Transcription factors | 499 |
Allergens | 507 |
Allergic bronchopulmonary aspergillosis | 518 |
Occupational Asthma | 529 |
Conclusions | 83 |
Structure and Function | 89 |
Ion channels | 96 |
Conclusion | 105 |
Mast Cells and Basophils | 113 |
Monocytes Macrophages and Dendritic Cells | 127 |
Effects of glucocorticoids on monocytemacrophage function | 134 |
Eosinophils | 141 |
Receptors and degranulation | 147 |
Lymphocytes | 159 |
defects in termination of immune responses may cause chronic disease | 176 |
Epithelial Cells | 187 |
Adhesion molecules and the airway epithelium | 194 |
Pathophysiology of Airway Mucus Secretion in Asthma | 205 |
Consequences of airway mucus hypersecretion and hyperviscosity | 213 |
Conclusions | 221 |
Tracheobronchial Circulation | 229 |
Adhesion Molecules | 239 |
In vivo studies of adhesion receptor antagonists in models of allergic | 246 |
Micro vascularEpithelial Exudation of Plasma | 253 |
Mucosal exudation of plasma in disease | 259 |
References | 265 |
Prostaglandins and Thromboxane | 269 |
Inhibitory prostaglandins | 275 |
Cysteinyl Leukotrienes | 281 |
Conclusions | 289 |
Kinins | 297 |
Summary | 303 |
Chemokines | 309 |
Chemokine receptors | 316 |
Lymphokines | 329 |
Other Mediators of Asthma | 343 |
Oxygen radicals | 349 |
References | 357 |
Nitric Oxide | 369 |
Exhaled NO | 375 |
Therapeutic implications | 382 |
Neural Control of Airway Function in Asthma | 389 |
Adrenergic control | 399 |
Humoral Control of Airway Tone | 409 |
Circulating inflammatory mediators | 415 |
NANC Nerves and Neuropeptides | 423 |
Tachykinins | 434 |
Other neuropeptides | 444 |
Transcription Factors | 459 |
JAKSTAT pathway | 465 |
Diagnosis of hypersensitivityinduced occupational asthma | 536 |
Management of occupational asthma | 542 |
Mechanisms of virusinduced airway hyperresponsiveness | 556 |
Summary | 564 |
Respiratory water loss and conditioning of inspired air | 570 |
Mechanisms by which a change in osmolarity and airway drying induce airway | 576 |
Atmospheric Pollutants | 589 |
Druginduced Asthma | 597 |
References | 603 |
Clinical presentation | 611 |
Allergen Avoidance | 617 |
Are threshold values useful? | 623 |
Allergen avoidance | 633 |
Allergen avoidance in asthma prevention | 640 |
Adrenoceptor Agonists | 651 |
Clinical pharmacology | 658 |
Anticholinergic Bronchodilators | 677 |
Sideeffects | 685 |
Effects | 693 |
Sideeffects | 701 |
Cromones | 707 |
References | 716 |
Glucocorticosteroids | 725 |
Effects on cell function | 732 |
Pharmacokinetics | 738 |
Clinical use of inhaled steroids | 745 |
Mediator Antagonists | 767 |
Plateletactivating factor PAF antagonists | 773 |
Immunomodulators | 783 |
Newer immunosuppressive agents | 790 |
New bronchodilators | 796 |
Cytokines and cytokine inhibitors | 805 |
Gene therapy | 813 |
Management of Severe Asthma | 821 |
Assisted ventilation | 827 |
Management of Asthma in Adults | 835 |
Treatment of the patient with severe persistent asthma | 852 |
Asthma in Children | 859 |
Assessment of the clinical condition | 865 |
Special age groups | 883 |
General measures | 889 |
Pharmacoeconomics of Asthma Treatments | 903 |
Conclusions | 914 |
Selfmanagement | 922 |
927 | |
Otras ediciones - Ver todo
Asthma: Basic Mechanisms and Clinical Management Peter J. Barnes,Ian W. Rodger,Neil C. Thomson No hay vista previa disponible - 1998 |
Términos y frases comunes
activation acute adrenoceptor agonists airway airway hyperresponsiveness airway narrowing airway responsiveness airway smooth muscle allergen allergen-induced Allergy Allergy Clin Immunol antagonists antibody antigen Appl Physiol asthmatic patients asthmatic subjects atopic atopy Barnes PJ bradykinin bronchial asthma bronchoconstriction bronchodilator budesonide chemokines cholinergic chronic Clin Exp Allergy clinical cytokines disease dose drugs effect endothelial endothelin eosinophil epithelial cells epithelium exposure expression gene glucocorticoids guinea-pig histamine human airways increased induced infection inhaled corticosteroids inhaled steroids inhibition inhibitors interleukin J-agonists leukotriene leukotriene D4 lung function lymphocytes macrophages mast cells mechanisms mediators methacholine monocytes mucosal mucus nedocromil nedocromil sodium nerves neuropeptides neutrophil NF-kB nitric oxide normal oral patients with asthma peptide Pharmacol plasma potent protein pulmonary receptor reduced release Respir Crit Respir Dis 1992 respiratory Rev Respir role salbutamol salmeterol severe asthma smooth muscle steroids stimulation studies symptoms T-cell theophylline therapy Thorax tissue tracheal treatment vitro vivo wheezing
Pasajes populares
Página 28 - J 1992; 305:1395-1399. 244. von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany.
Página 60 - Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T: Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis (1985) 131: 599-606.