Asthma: Basic Mechanisms and Clinical Management

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Peter J. Barnes, Ian W. Rodger, Neil C. Thomson
Elsevier, 20 abr 1998 - 942 páginas
Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field.
  • Comprehensive coverage of both basic science and clinical aspects of asthma
  • Extensively referenced throughout
 

Índice

Chapter 2 Genetics
35
Chapter 3 Airway Pathology in Asthma
47
Chapter 4 Physiology
65
Structure and Function
89
Chapter 6 Mast Cells and Basophils
113
Chapter 7 Monocytes Macrophages and Dendritic Cells
127
Chapter 8 Eosinophils
141
Chapter 9 Lymphocytes
159
Chapter 26 Airway Remodelling
475
Chapter 27 Pathophysiology of Asthma
487
Chapter 28 Allergens
507
Chapter 29 Occupational Asthma
529
Chapter 30 Infections
547
Chapter 31 Asthma Provoked by Exercise Hyperventilation and the Inhalation of Nonisotonic Aerosols
569
Chapter 32 Atmospheric Pollutants
589
Chapter 33 Druginduced Asthma
597

Chapter 10 Epithelial Cells
187
Chapter 11 Pathophysiology of Airway Mucus Secretion in Asthma
205
Chapter 12 Tracheobronchial Circulation
229
Chapter 13 Adhesion Molecules
239
Chapter 14 MicrovascularEpithelial Exudation of Plasma
253
Chapter 15 Prostaglandins and Thromboxane
269
Chapter 16 Cysteinyl Leukotrienes
281
Chapter 17 Kinins
297
Chapter 18 Chemokines
309
Color Plate Section
326
Chapter 19 Lymphokines
329
Chapter 20 Other Mediators of Asthma
343
Chapter 21 Nitric Oxide
369
Chapter 22 Neural Control of Airway Function in Asthma
389
Chapter 23 Humoral Control of Airway Tone
409
Chapter 24 NANC Nerves and Neuropeptides
423
Chapter 25 Transcription Factors
459
Chapter 34 Aspirininduced Asthma
607
Chapter 35 Allergen Avoidance
617
Chapter 36 BAdrenoceptor Agonists
651
Chapter 37 Anticholinergic Bronchodilators
677
Chapter 38 Theophylline
689
Chapter 39 Cromones
707
Chapter 40 Glucocorticosteroids
725
Chapter 41 Mediator Antagonists
767
Chapter 42 Immunomodulators
783
Chapter 43 Future Therapies for Asthma
795
Chapter 44 Management of Severe Asthma
821
Chapter 45 Management of Asthma in Adults
835
Chapter 46 Asthma in Children
859
Chapter 47 Pharmacoeconomics of Asthma Treatments
903
Chapter 48 Education and Selfmanagement
917
Index
927
Página de créditos

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Términos y frases comunes

Pasajes populares

Página 28 - J 1992; 305:1395-1399. 244. von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany.
Página 60 - Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T: Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis (1985) 131: 599-606.

Sobre el autor (1998)

Peter Barnes is Professor of Thoracic Medicine at the National Heart and Lung Institute, Head of Respiratory Medicine at Imperial College and Honorary Consultant Physician at Royal Brompton Hospital, London. He qualified at Cambridge and Oxford Universities was appointed to his present post in 1987. He has published over 1000 peer-review papers on asthma, COPD and related topics and has edited over 40 books. He is also amongst the top 50 most highly cited researchers in the world and has been the most highly cited clinical scientist in the UK and the most highly cited respiratory researcher in the world over the last 20 years. He was elected a Fellow of the Royal Society in 2007, the first respiratory researcher for over 150 years. He is currently a member of the Scientific Committee of the WHO/NIH global guidelines on asthma (GINA) and COPD (GOLD). He also serves on the Editorial Board of over 30 journals and is currently an Associate Editor of Chest and respiratory Editor of PLoS Medicine. He has given several prestigious lectures, including the Amberson Lecture at the American Thoracic Society and the Sadoul Lecture at the European Respiratory Society.

Neil Thomson is Professor of Respiratory Medicine at the University of Glasgow, Head of Respiratory Medicine within the Division of Immunology, Infection & Inflammation and Honorary Consultant at Gartnavel General Hospital, Glasgow. He graduated from the University of Glasgow and undertook postgraduate training in Glasgow, London and McMaster University, Canada. He is a former member of the Committee for Safety of Medicine and former Chair of the Scientific Committee of the British Lung Foundation. He has co-edited several textbooks on asthma and COPD and published over 150 peer-reviewed papers on asthma. His current research interests include corticosteroid insensitivity in smokers with asthma, biomarkers in asthma and COPD and assessment of novel treatments for asthma.

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