Asthma: Basic Mechanisms and Clinical Management

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Peter J. Barnes, Ian W. Rodger, Neil C. Thomson
Elsevier, 20 abr. 1998 - 942 páginas
Now available in its Third Edition, Asthma: Basic Mechanisms and Clinical Management has become the reference text in asthma. This highly successful text sheds new light on the basic physiological and molecular mechanisms of asthma, how current treatments work, and how best to apply the latest knowledge to control this important disease. The Third Edition has undergone radical revision and includes several new chapters. It retains the virtues of the previous volumes by bringing together all of the recent research findings by internationally recognized experts on the causative mechanisms of asthma, including in-depth clinical aspects and therapy. The book presents an integrated approach toward the treatment of this disease with new concepts, changes in asthma management, and the development of new therapeutic agents. Asthma provides extensive references for researchers and clinicians who need to keep abreast of recent developments in this rapidly expanding field.
  • Comprehensive coverage of both basic science and clinical aspects of asthma
  • Extensively referenced throughout
 

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Índice

References
471
Extracellular matrix
478
References
484
Structural cells
491
Transcription factors
499
Allergens
507
Allergic bronchopulmonary aspergillosis
518
Occupational Asthma
529

Conclusions
83
Structure and Function
89
Ion channels
96
Conclusion
105
Mast Cells and Basophils
113
Monocytes Macrophages and Dendritic Cells
127
Effects of glucocorticoids on monocytemacrophage function
134
Eosinophils
141
Receptors and degranulation
147
Lymphocytes
159
defects in termination of immune responses may cause chronic disease
176
Epithelial Cells
187
Adhesion molecules and the airway epithelium
194
Pathophysiology of Airway Mucus Secretion in Asthma
205
Consequences of airway mucus hypersecretion and hyperviscosity
213
Conclusions
221
Tracheobronchial Circulation
229
Adhesion Molecules
239
In vivo studies of adhesion receptor antagonists in models of allergic
246
Micro vascularEpithelial Exudation of Plasma
253
Mucosal exudation of plasma in disease
259
References
265
Prostaglandins and Thromboxane
269
Inhibitory prostaglandins
275
Cysteinyl Leukotrienes
281
Conclusions
289
Kinins
297
Summary
303
Chemokines
309
Chemokine receptors
316
Lymphokines
329
Other Mediators of Asthma
343
Oxygen radicals
349
References
357
Nitric Oxide
369
Exhaled NO
375
Therapeutic implications
382
Neural Control of Airway Function in Asthma
389
Adrenergic control
399
Humoral Control of Airway Tone
409
Circulating inflammatory mediators
415
NANC Nerves and Neuropeptides
423
Tachykinins
434
Other neuropeptides
444
Transcription Factors
459
JAKSTAT pathway
465
Diagnosis of hypersensitivityinduced occupational asthma
536
Management of occupational asthma
542
Mechanisms of virusinduced airway hyperresponsiveness
556
Summary
564
Respiratory water loss and conditioning of inspired air
570
Mechanisms by which a change in osmolarity and airway drying induce airway
576
Atmospheric Pollutants
589
Druginduced Asthma
597
References
603
Clinical presentation
611
Allergen Avoidance
617
Are threshold values useful?
623
Allergen avoidance
633
Allergen avoidance in asthma prevention
640
Adrenoceptor Agonists
651
Clinical pharmacology
658
Anticholinergic Bronchodilators
677
Sideeffects
685
Effects
693
Sideeffects
701
Cromones
707
References
716
Glucocorticosteroids
725
Effects on cell function
732
Pharmacokinetics
738
Clinical use of inhaled steroids
745
Mediator Antagonists
767
Plateletactivating factor PAF antagonists
773
Immunomodulators
783
Newer immunosuppressive agents
790
New bronchodilators
796
Cytokines and cytokine inhibitors
805
Gene therapy
813
Management of Severe Asthma
821
Assisted ventilation
827
Management of Asthma in Adults
835
Treatment of the patient with severe persistent asthma
852
Asthma in Children
859
Assessment of the clinical condition
865
Special age groups
883
General measures
889
Pharmacoeconomics of Asthma Treatments
903
Conclusions
914
Selfmanagement
922
Index
927
Página de créditos

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Términos y frases comunes

Pasajes populares

Página 28 - J 1992; 305:1395-1399. 244. von Mutius E, Martinez FD, Fritzsch C, Nicolai T, Roell G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany.
Página 60 - Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T: Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis (1985) 131: 599-606.

Sobre el autor (1998)

Peter Barnes is Professor of Thoracic Medicine at the National Heart and Lung Institute, Head of Respiratory Medicine at Imperial College and Honorary Consultant Physician at Royal Brompton Hospital, London. He qualified at Cambridge and Oxford Universities was appointed to his present post in 1987. He has published over 1000 peer-review papers on asthma, COPD and related topics and has edited over 40 books. He is also amongst the top 50 most highly cited researchers in the world and has been the most highly cited clinical scientist in the UK and the most highly cited respiratory researcher in the world over the last 20 years. He was elected a Fellow of the Royal Society in 2007, the first respiratory researcher for over 150 years. He is currently a member of the Scientific Committee of the WHO/NIH global guidelines on asthma (GINA) and COPD (GOLD). He also serves on the Editorial Board of over 30 journals and is currently an Associate Editor of Chest and respiratory Editor of PLoS Medicine. He has given several prestigious lectures, including the Amberson Lecture at the American Thoracic Society and the Sadoul Lecture at the European Respiratory Society.

Neil Thomson is Professor of Respiratory Medicine at the University of Glasgow, Head of Respiratory Medicine within the Division of Immunology, Infection & Inflammation and Honorary Consultant at Gartnavel General Hospital, Glasgow. He graduated from the University of Glasgow and undertook postgraduate training in Glasgow, London and McMaster University, Canada. He is a former member of the Committee for Safety of Medicine and former Chair of the Scientific Committee of the British Lung Foundation. He has co-edited several textbooks on asthma and COPD and published over 150 peer-reviewed papers on asthma. His current research interests include corticosteroid insensitivity in smokers with asthma, biomarkers in asthma and COPD and assessment of novel treatments for asthma.

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