New and Exploratory Therapeutic Agents for Asthma

Portada
CRC Press, 12 nov 1999 - 528 páginas
Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches!
This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies.
Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma.
Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma
  • explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system
  • examines the role of monoclonal antibodies in allergy and asthma
  • describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids
  • investigates the controversy of different types of asthma
  • illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation
  • assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties
  • reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics
  • evaluates the relationship between improvements in laboratory results and clinical effectiveness
  • and more!
    Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical school students in these disciplines.
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    Índice

    1 Epidemiology of Asthma
    1
    2 Pathophysiology of Asthma
    26
    3 Pathology of Asthma
    54
    4 Muscarinic Receptor Subtypes and Anticholinergic Therapy
    78
    5 LongActing β2Agonist Drugs
    110
    6 Inhaled Glucocorticoids Established and New
    145
    7 PlateletActivating Factor Antagonists in Bronchial Asthma
    170
    8 Tachykinin Receptor Antagonists
    188
    10 Therapeutic Potential of Phosphodiesterase Type 4 Inhibitors in the Treatment of Asthma
    200
    11 The AntiIgE Treatment Strategy for Asthma
    286
    12 Activity of TCell Subsets in Allergic Asthma
    299
    13 New Targets for Future Asthma Therapy
    316
    14 Current Practice and Future Trends in Clinical Trials in Asthma
    345
    Author Index
    357
    Subject Index
    474
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