Handbook of Drug Screening

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Ramakrishna Seethala, Prabhavathi Fernandes
CRC Press, 24 jul. 2001 - 520 páginas
A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies.
 

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Índice

2 Basic Considerations in Designing HighThroughput Screening Assays
5
3 Screening Platforms
31
4 Homogeneous Assays for HighThroughput and UltrahighThroughput Screening
69
5 MicrobeBased Screening Systems
129
6 Molecular Genetic Screen Design for Agricultural and Pharmaceutical Product Discovery
153
7 Receptor Screens for Small Molecule Agonist and Antagonist Discovery
189
8 Functional Assay Screens
265
9 Enzyme Screens
283
13 HigherThroughput Screening Assays With Human Hepatocytes for HepatotoxicityMetabolic Stabilityand Drug Drug Interaction Potential
383
14 HighThroughput Screening for MetabolismBased Drug Drug Interactions
403
15 The ATCG of Drug Discovery
415
16 GenomicsFunctional Proteomics for Identi cation of New Targets
433
17 Bioinformatics
447
18 The Evolution of Laboratory Automation
477
19 Robotics and Automation
493
20 Assay Miniaturization
525

10 Screening Strategies for Ion Channel Targets
313
11 HighThroughput Screening Assays for Detection of Transcription
335
12 Screening of Combinatorial Biology Libraries for Natural Products Discovery
357
21 Screening in the NanoWorld
563
Index
583
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