Down Syndrome and Alzheimer's Disease: Biological CorrelatesVee P. Prasher Radcliffe Publishing, 2006 - 184 páginas This is the first book in the field to address the underlying biological abnormalities of Dementia in Alzheimer's Disease (DAD) in people with Down syndrome. It brings together research findings relating to the neuropathology, genetics, blood markers and neurophysiology of Alzheimer's disease in older adults with Down syndrome. Down Syndrome and Alzheimer's Disease presents vital information to medical professionals who provide clinical care to people with Alzheimer's disease and Down syndrome. It will also be of great benefit to researchers with an interest in Alzheimer's disease and Down syndrome and academics researching ageing issues in people with Down Syndrome. It complements Alzheimer's Disease and Dementia in Down Syndrome and Intellectual Disabilities by the same author. |
Índice
Neuropathology of Alzheimers disease in Down syndrome | 15 |
Genetics Alzheimers disease and Down syndrome | 37 |
Amyloid beta and tau proteins in Alzheimers disease and Down | 59 |
Down syndrome dementia and superoxide dismutase | 79 |
Thyroid disorders dementia and Down syndrome | 99 |
Neurophysiological changes associated with dementia in Down | 141 |
Neuroimaging studies of individuals with Down syndrome | 157 |
Concluding remarks | 177 |
Otras ediciones - Ver todo
Down Syndrome and Alzheimer's Disease: Biological Correlates Vee P. Prasher Vista de fragmentos - 2006 |
Términos y frases comunes
abnormalities adults with DS age-related allele Alzheimer disease Alzheimer's disease amyloid beta amyloid precursor protein Ann Neurol ApoE 4 allele apolipoprotein Arch Neurol Aẞ42 levels associated autoimmune blood brain anatomy cell cerebral cerebrospinal fluid chromosome 21 Clin clinical cognitive function congenital hypothyroidism correlation cortex CSF tau decreased demented deposition diagnosis disease and Down's Down's syndrome elderly factors gene genetic glucose glutathione peroxidase H-MRS healthy controls hippocampus hypothyroidism increased individuals with DS intellectual disability iodine late-onset macrocytosis Mann DMA marker measures mental retardation metabolism myo-inositol Neurobiol neurofibrillary neurofibrillary tangles Neurology neuropathological Neurosci Lett non-demented adults non-demented individuals normal older onset of dementia overexpression P300 latency pathological patients with DS plasma population Prasher VP presenilin Psychiatry reported risk selenium significant significantly subclinical superoxide dismutase tau protein telomere thyroid disease thyroid dysfunction thyroid function thyroid hormone trisomy TSH levels volumetric MRI studies zinc