Liver Diseases: Targeted Diagnosis and Therapy Using Specific Receptors and LigandsGeorge Y. Wu, Catherine Y. Wu CRC Press, 29 may 1991 - 376 páginas This reference presents novel approaches to achieve biological specificity using naturally existing cell-surface structures. Demonstrating the strategies and logic applied in the design of liver-specific agents, this resource bridges the gap between basic science and clinical medicine. |
Índice
Trafficking of Asialoglycoproteins and the Asialoglycoprotein Receptor | 3 |
Structural Characteristics and Regulation of the Asialoglycoprotein | 41 |
Ligand Structural Requirements for Recognition and Binding by | 65 |
Targeting of Liposomes to Hepatocytes | 87 |
ReceptorMediated Protection of Normal Hepatocytes During | 105 |
Targeted Delivery and Expression of Foreign Genes in Hepatocytes | 127 |
Asialoglycoproteins as Radiodiagnostic Agents for Detection | 151 |
Contrast Agents for Magnetic Resonance Imaging of the Liver | 163 |
Mechanism and Clinical Relevance of Elevated Levels | 215 |
Limitations on the Specificity of Targeting AsialoglycoproteinDrug | 235 |
Trafficking of the Transferrin Receptor | 267 |
Mechanism and Clinical Significance of Soluble Hepatic CellSurface | 305 |
ReceptorMediated Radiopharmaceutical Imaging of the Liver | 321 |
Ferritin Receptors and the Role of Ferritin in Iron Transport | 339 |
| 355 | |
Effect of Ethanol on Asialoglycoprotein Receptor Function | 189 |
Términos y frases comunes
Acad acid affinity albumin antibody ASGP receptor ASGP-R Ashwell asialofetuin asialoglycoprotein receptor asialoorosomucoid ASOR assay binding Biochem Biophys carbohydrate Cell Biol cell line cell surface Chem chronic cirrhosis clathrin coated pits coated vesicles compartment complex conjugate containing contrast agents decreased degradation density drug effect endocytic endosomes enzyme ethanol ferritin function galactosamine galactose gene Geuze glycoproteins Golgi Hep G2 cells hepatic lectin hepatocellular carcinoma hepatocytes Hepatology hepatoma hepatoma cells human imaging increased incubated inhibition inhibitor injected internalization intracellular intravenously iron kinetics Kupffer cells labeled lectin ligand liposomes liver cells liver disease lysosomes magnetic mediated metabolism molecular molecules Natl neoglycoproteins organelles pathway patients perfused plasma membrane polypeptide Proc protein rat hepatocytes rat liver receptor activity receptor recycling receptor-mediated endocytosis residues RHL1 role Schwartz serum sinusoidal specific Stockert structure studies subunits surface receptors targeted tion tissue toxicity transferrin receptor transport tumor uptake vesicles vitro vivo
Pasajes populares
Página xiii - Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda, Maryland KENNETH V.