Familial Cancer and Prevention: Molecular Epidemiology: A New Strategy Toward Cancer Control
A New Strategy Toward Cancer Control.
Still in its infancy, the familial/hereditary approach to cancer control is proving to be one of the most potent strategies in the war on cancer. Over the past few years the human genome project has generated an abundance of valuable information on the genetic origins of a range of cancers. Tests now exist for several hereditary, tumor-promoting genetic mutations-including those found in BRCA genes associated with breast cancer as well as mutations of HNPCC genes which have been linked to colon cancers-and many more are anticipated in the near future. Armed with the information yielded by these tests, physicians have already saved countless lives through preventative counseling, early detection, and more highly-focused intervention strategies.
Inspired by the proceedings of the UICC 1997 Symposium on Familial Cancer and Prevention held in Kobe, Japan, this volume provides clinicians and researchers with a detailed review of the latest developments at the front lines of the familial cancer prevention movement. In a series of edited contributions, leading researchers and clinicians from around the globe summarize their experiences and analyze current and emerging trends in:
* Information gathering and history taking.
* Risk assessment.
* Genetic testing for colorectal, endocrine, breast, and other familial cancers.
* Diagnosis, prognosis, and management of an array of familial cancers.
* Genetic counseling for familial cancers.
Up-to-date, authoritative, and comprehensive, Familial Cancer and Prevention is an important working resource for clinicians, cancer researchers, and epidemiologists.
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Molecular Epidemiology of Human Cancer
The Rationale of a Questionnaire
ObjectOriented Computer Software Linking a Pedigree Drawing
Research and Clinical Care Networks in Neurofibromatosis
Experience of the First
Family HistoryBased Screening for Colorectal Cancer
Characteristics of 552 Consultees
Genetic Diagnosis and Management of Suspected Hereditary
A Trial of Aspirin andor
Dietary Prevention of Colorectal Cancer
Calcium in Cancer Prevention
Phase III MultipleDose Safety and Efficacy Clinical
The Impact of Living With Hereditary Colorectal Disease
The Tata Memorial
Efficacy of a Clinical Risk
Hereditary Tumor Registry in Korea
The Parallel With
A Nursing Perspective of Counseling Families in a Cancer
The Nurses Role in Decision Making in Familial Cancer
New and Evolving Challenges for Oncology
Genetic Counseling and Its Ethical Issues in Japan
Bioethical Concerns With Rights of Patients Receiving
Use of Genetic Information by Private Insurers
Familial Adenomatous Polyposis
Extracolonic Symptoms of Familial Adenomatous Polyposis
Desmoid Disease in Familial Adenomatous Polyposis
Chemoprevention of Colorectal Adenomas in Familial
Interventional Trial for Cancer Prevention for Familial
Colorectal Cancer Prognosis in Hereditary Nonpolyposis
Evolution of Neoplasia in Hereditary Nonpolyposis
Controversial Issues in Hereditary Nonpolyposis Colorectal Cancer
Benign Extracolonic Manifestations Associated With Hereditary
An Automated Genetic Assay for Hereditary Nonpolyposis
Complex Genetic Predisposition to Cancer in an Extended
Surveillance and Management of Hereditary Nonpolyposis
GeneDiet Interactions and the High Colorectal Cancer Risk
Impact of Migration on the Phenotypes of Familial Cancer
Mutagen Sensitivity as a Predisposing Factor in the Identification
Genetic Alterations in Esophageal Cancers
Identification and Characterization of Families With Aggregation
Inherited Medullary Thyroid Carcinoma in Japan
Management of Hereditary Medullary Thyroid Carcinoma
Consequences of Specific RET Gene Mutations in Families With
Recurrent Loss of Heterozygosity for Chromosome 1p in Siblings
Recent Developments in the Genetic Epidemiology of Breast Cancer
Mapping of NonBRCA12 Breast Cancer Genes
A Novel 150K Marker for Early Human Mammary Carcinoma
Endocrine Approaches to Breast Cancer Prevention
DNABased Genetic Counseling
Case Series Compared
Progress in the Diagnosis and Management of Neurofibromatosis
Cancer Genetics of the Tuberous Sclerosis TSC2 Gene Mutant
Cutaneous Malignant Melanoma
Adult Progeria With CancerProne Inheritance
UICC Molecular Biology Workshop Report
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adenomas alleles Amsterdam criteria analysis APC gene associated BRCA1 BRCA2 breast cancer Cancer and Prevention cancer families cancer genetic cancer patients cancer risk cancer susceptibility carcinogenesis carcinoma cell chemoprevention chromosome clinical codon colectomy colon cancer colorectal cancer colorectal cancer HNPCC database desmoid detection diagnosis disease Edited by Utsunomiya effect Epidemiology extracolonic familial adenomatous polyposis Familial Cancer family history family members FMTC gene carriers genetic counseling genetic testing germline mutations hereditary cancer hereditary nonpolyposis colorectal Hereditary Tumor HNPCC HNPCC patients Hospital human identified individuals inherited ISBN Japan Japanese lesions Lynch HT malignant melanoma MEN2A microsatellite mismatch repair genes molecular multiple Mulvihill neoplasia nonpolyposis colorectal cancer Oncology oral cancer ovarian cancer pedigree phenotype polyps predisposition prophylactic protein rectal Registry Research retinoblastoma screening sporadic sulindac Surgery surveillance syndrome thyroid tissue TP53 mutations TSC2 University Utsunomiya Weber Wiley-Liss