Diagnostic and Therapeutic Advances in Pediatric Oncology

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David O. Walterhouse, Susan L. Cohn
Springer Science & Business Media, 31 ene. 1998 - 387 páginas
The purpose of Diagnostic and Therapeutic Advances in Pediatric Oncology for the Cancer Treatment and Research Series is to provide an up-to-date summary of how recent advances in cancer research are being applied to the care of children with solid tumors. The interface of cancer research with clinical practice in pediatric oncology has never been more intimate than today. While researchers are identifying oncogenes and tumor suppressor genes and are studying their specific functions, clinicians are using knowledge of oncogenes and tumor suppressor genes for diagnosing cancer in children, for therapeutic decision-making purposes, and for prognostic purposes. The first three chapters in this book describe models for understanding the causes of childhood cancer that were perhaps initially identified by clinicians and that are now being studied and understood by researchers. These chapters will describe research evidence that supports roles for the involvement of normal developmental regulatory genes in childhood oncogenesis, of abnormal immune regulation in childhood oncogenesis, and of heredity in childhood oncogenesis. The next eight chapters are devoted to descriptions of the appli cation of new research developments to clinical practice with reference to the most common forms of solid tumors of childhood outside the central nervous system. The final chapter will describe late effects of childhood cancer and its therapy and the impact research is having on understanding and perhaps preventing these late effects.
 

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Índice

Embryonic Development and Pediatric Oncogenesis
3
Immunodeficiency states and related malignancies
39
Familial cancer syndromes and genetic counseling
63
Embryonal Tumors
99
Molecular basis of Wilms tumor
101
Neuroblastoma Solving a Biologic Puzzle
125
Pediatric Germ Cell Tumors
163
Hepatic Malignancies in Childhood and Adolescence Hepatoblastoma Hepatocellular Carcinoma and Embryonal Sarcoma
201
Sarcomas
213
Osteosarcoma
215
The Ewings Sarcoma Family of Tumors Ewings Sarcoma and Peripheral Primitive Neuroectodermal Tumor of Bone and Soft Tissue
253
Rhabdomyosarcoma Biology and Therapy
309
Late Effects of Childhood Cancer
341
Late Effects of Cancer Therapy
343
Index
377
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