Diagnostic and Therapeutic Advances in Pediatric OncologyDavid O. Walterhouse, Susan L. Cohn Springer Science & Business Media, 31 ene 1998 - 387 páginas The purpose of Diagnostic and Therapeutic Advances in Pediatric Oncology for the Cancer Treatment and Research Series is to provide an up-to-date summary of how recent advances in cancer research are being applied to the care of children with solid tumors. The interface of cancer research with clinical practice in pediatric oncology has never been more intimate than today. While researchers are identifying oncogenes and tumor suppressor genes and are studying their specific functions, clinicians are using knowledge of oncogenes and tumor suppressor genes for diagnosing cancer in children, for therapeutic decision-making purposes, and for prognostic purposes. The first three chapters in this book describe models for understanding the causes of childhood cancer that were perhaps initially identified by clinicians and that are now being studied and understood by researchers. These chapters will describe research evidence that supports roles for the involvement of normal developmental regulatory genes in childhood oncogenesis, of abnormal immune regulation in childhood oncogenesis, and of heredity in childhood oncogenesis. The next eight chapters are devoted to descriptions of the appli cation of new research developments to clinical practice with reference to the most common forms of solid tumors of childhood outside the central nervous system. The final chapter will describe late effects of childhood cancer and its therapy and the impact research is having on understanding and perhaps preventing these late effects. |
Índice
Embryonic Development and Pediatric Oncogenesis | 3 |
Immunodeficiency states and related malignancies | 39 |
Familial cancer syndromes and genetic counseling | 63 |
Embryonal Tumors | 99 |
Molecular basis of Wilms tumor | 101 |
Neuroblastoma Solving a Biologic Puzzle | 125 |
Pediatric Germ Cell Tumors | 163 |
Hepatic Malignancies in Childhood and Adolescence Hepatoblastoma Hepatocellular Carcinoma and Embryonal Sarcoma | 201 |
Sarcomas | 213 |
Osteosarcoma | 215 |
The Ewings Sarcoma Family of Tumors Ewings Sarcoma and Peripheral Primitive Neuroectodermal Tumor of Bone and Soft Tissue | 253 |
Rhabdomyosarcoma Biology and Therapy | 309 |
Late Effects of Childhood Cancer | 341 |
Late Effects of Cancer Therapy | 343 |
377 | |
Otras ediciones - Ver todo
Diagnostic and Therapeutic Advances in Pediatric Oncology David O. Walterhouse,Susan L. Cohn Vista previa restringida - 2012 |
Diagnostic and Therapeutic Advances in Pediatric Oncology David O. Walterhouse,Susan L. Cohn No hay ninguna vista previa disponible - 2012 |
Diagnostic and Therapeutic Advances in Pediatric Oncology David O Walterhouse,Susan L Cohn No hay ninguna vista previa disponible - 1998 |
Términos y frases comunes
abnormalities Acad Sci USA adjuvant adolescents allele amplification analysis associated Biol biopsy bone marrow Cancer Res carcinoma chemotherapy childhood cancer chromosome cisplatin Clin Oncol clinical cyclophosphamide Cytogenet deletion diagnosis differentiation disease domain dose doxorubicin Drosophila embryonal endodermal sinus tumor ESFT etoposide Ewing's sarcoma expression factors function genomic germ cell tumors germline growth hepatoblastoma histologic homeobox HOX genes Hum Genet human ifosfamide IGF2 immature teratomas imprinting Intergroup irradiation late effects lesions leukemia liver locus lymph nodes lymphoma malignant metastatic mice molecular mutations MYCN N-myc neoplasms neural neuroblastoma normal oncogene osteosarcoma outcome ovarian Pathol patients pattern PAX3 Pediatric Oncology phenotype polyposis primary prognostic protein pulmonary radiation therapy radiotherapy recurrence regimens region renal reported resection response retinoblastoma risk role soft tissue stage surgery surgical survivors syndrome testicular tion transcription translocation treated treatment trials tumor suppressor gene vincristine Wilms