Leading Pharmaceutical Innovation: Trends and Drivers for Growth in the Pharmaceutical Industry

Portada
Springer Science & Business Media, 19 feb. 2008 - 186 páginas
Pharmaceutical giants have doubled their investments in drug development in the past decade only to see new drug approvals remain constant. This book investigates and highlights a set of proactive strategies aimed at generating sustainable competitive advantage based on value-generating business practices. We focus on three sources of pharmaceutical innovation: new management methods in the drug development pipeline, new technologies as enablers for cutting-edge R&D, and new forms of cooperation and internationalization, such as open innovation in the early phases of R&D. Our findings are illustrated by cases from Europe, the US, and Asia.
 

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Índice

Innovation Key to Success in the Pharmaceutical Industry
1
The Blockbuster Imperative
4
High Risks in Drug Development
10
Strategies for Growth
12
Differentiation via Clinical Profiles
15
Entering the Market Quickly
16
Conclusions
17
The Industry Challenge Do You Really Want to Be in This Business?
19
Rising Importance of RD Collaborations
75
Accessing Earlystage Innovation
78
Enhancing the Innovation Pipeline
81
Mutually Benefiting from Joint Resources
83
Commercializing Internal Research Results
86
How to Commercialize a Breakthrough Technology
95
Conclusions
100
The Internationalization Challenge Where to Get Access to Innovation
103

How Attractive is the Pharmaceutical Industry?
22
Bargaining Power of Suppliers
24
Bargaining Power of Buyers
25
Risk of Entry from Potential Competitors
26
Threat of Substitute Products
27
Rivalry among Established Companies
28
Conclusions
30
The Science and Technology Challenge How to Find New Drugs
33
Fail Earlier Succeed Sooner
38
Cut Experimental Cycle Times
39
More than 100 Gigabytes of Data per Day
40
Profiting from the Human Genome Project
42
Towards Individualization and Mass Customization
43
Create Tailormade Drugs
45
From Experimenting to Analytic Design
47
Conclusions
48
The Pipeline Management Challenge How to Organize Innovation
50
Complexity and Phases of the RD Process
56
The Importance of Project and Portfolio Management
65
The Disaggregation of the Pharmaceutical Value Chain
68
Impact of Outsourcing on Pharmaceutical RD
71
Primary Locations of Pharmaceutical RD around the World
108
New Opportunities for Drug Development in China
111
Three Principal Problems of Dispersed RD
117
Conclusions
121
Management Answers to Pharmaceutical RD Challenges
123
Managing RD Strategy at Schering
125
Managing the ResearchtoDevelopment Handover at Roche
127
Managing Outsourcing Activities at Solvias
130
Managing Intellectual Property Rights at Bayer
133
Managing Outlicensing at Novartis
137
Managing Uncertainty at Roche
144
Managing Global RD at Major Swiss Pharma Companies Switzerland as RD location
145
Managing a NicheMarket Strategy at Intarcia
151
Managing Virtual Project Management Pools at Roche
153
Conclusions
156
Future Directions and Trends
158
Bibliography
165
Index
173
Glossary
179
Authors
185
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