Molecular Biology of the Lung: Asthama and CancerRobert A. Stockley Springer Science & Business Media, 1998 - 204 páginas The purpose of this two-volume work is to provide an update on the use of this powerful technology. As such, the books provide an insight in to the techniques for the non-specialist. Scientists embarking upon st udies in chronic lung disease will find a review of the current status of research. At the same time, the books are useful to clinicians, bo th specialist and academic, and to scientists already involved in the basic aspects of the pathogenesis of lung disease. Both volumes deal w ith basic mechanisms of cell biology, receptors and cellactivation and provide an insight as to how the technology influences our concepts o f pathogenesis and viceversa. |
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a₁-antitrypsin Acad Sci USA activation adenoviral vectors adhesion molecules airway smooth muscle alleles allergen amino acid antibodies antigen apoptosis associated asthma atopic atopy Barnes PJ binding Biol Chem bronchial Cancer Res carcinoma CC chemokines cDNA cell lines cell lung chemoattractant chemokines chromosome clinical cloning corticosteroids CREB cytokines disease down-regulation E-selectin effects endothelial cells enzyme eosinophil eotaxin epithelial cells function gene delivery gene expression gene therapy gene transfer genetic glucocorticoid GM-CSF house dust mite human lung immune increased induced inflammation inflammatory inhibition interaction interleukin kinase leukocyte ligand linkage lung cancer lymphocytes mediated mice molecular mouse mRNA mutations Natl Acad Sci NF-AT NF-kB oncogenes P-selectin pathways patients phenotype phosphorylation polymorphisms Proc Natl Acad promoter protein proteinase pulmonary receptor region regulation Respir Cell Mol Respir Crit retroviral role SCLC sequence specific ẞ-adrenergic ẞ-agonists ẞ2-receptor steroids target therapeutic tion tissue transcription factors transfected tumour cells viral virus vitro vivo