Laragh's Lessons in Renin System Pathophysiology for Treating Hypertension and Its Fatal Cardiovascular Consequences

Here's an essential reference for anyone needing an advanced understanding of the nature and treatment of hypertension. Dr. Laragh, a pioneering clinician and scientist, demonstrates the central role of an overactive renin system for causing most hypertension. In his new book, Dr. Laragh discusses his research and its relevance to caring for everything from asymptomatic patients to hypertensive emergencies. And, he provides visit-by-visit details of his new pathophysiologically and biochemically guided treatment. The result of his work is a specific approach that makes it possible to more effectively prevent, arrest, and treat hypertension and its consequences-including congestive heart failure, myocardial infarction, kidney failure and stroke.

Defined three anti-renin R drug classes: beta blockers

intravenous converting enzyme inhibitors

and angiotensin receptor blockers, and showed the direct correlations between the depressor effectiveness of each of these drugs and the height of baseline rennin levels of each patient.

Originated the strategy of using plasma renin testing to determine whether the sodium volume V mediates a patient's hypertension or the rennin vasoconstriction R factor in order to prescribe the appropriate V or R drug treatment.