Childhood LeukemiasChing-Hon Pui Cambridge University Press, 21 jun 2012 - 892 páginas "In the five years since publication of the second edition of Childhood Leukemias, new insights into the molecular and cellular biology of cancers in general, and of the leukemias in particular, have catalyzed exciting advances in diagnostic methods, strategies of risk assessment and the development of targeted and other novel forms of treatment. Encouraged by this progress, and the enthusiastic responses of readers of the previous edition, I willingly accepted the invitation to develop a third edition of this successful book. The rapid growth in our understanding of the biology of childhood leukemias and the accelerating pace of innovations in diagnostic and therapeutic approaches presented a considerable challenge during revision of the second edition. As you will notice, each chapter has been extensively modified or rewritten to accommodate the most recent information and references. Although structured to emphasize emerging themes in leukemia pathobiology and treatment, the reworked book still seeks to maintain a balance between fundamental pathophysiology and practical approaches to patient management, a standard that was central to the success of our earlier editions.Three chapters are entirely new. One deals with the epigenetics of leukemia, a topic that hasmoved rapidly to the fore of leukemia research.The discovery that aberrant epigenetic changes often cooperate with DNA sequence alterations in the initiation and progression of cancer, and that such changes are potentially reversible, has already led to clinical trials of therapies based on key epigenetic findings"--Provided by publisher. |
Índice
25 | 9 |
Diagnosis and classification | 21 |
Mihaela Onciu and ChingHon Pui Acute lymphoblastic leukemia 332 | 49 |
Logan G Spector Bridget Charbonneau and Relapsed acute lymphoblastic leukemia | 367 |
Bcell acute lymphoblastic leukemia | 383 |
lmmunophenotyping 72 | 395 |
lmmunoglobulin and Tcell receptor gene | 421 |
M van Dongen and Anton W Langerak Ursula CreutZig | 429 |
Molecular genetics of acute myeloid Ieffrey W Taub April Sorrell and James A Whitlock | 520 |
Epigenetics of leukemia 239 Iames Nachman | 527 |
Heritable predisposition to childhood | 549 |
hematologic malignancies 276 Raul C Ribeiro Scott C Howard and ChingHon | 563 |
Complications and supportive care | 660 |
Late complications after leukemia therapy | 701 |
34 | 714 |
851 | |
Molecular genetics of acute lymphoblastic Chronic myeloproliferative disorders | 444 |
Charles G Mullighan 20 Leukemias in patients with Down syndrome | 503 |
Otras ediciones - Ver todo
Términos y frases comunes
abnormalities Acad Sci USA acid activity acute leukemia acute lymphoblastic leukemia acute myeloid leukemia acute promyelocytic leukemia adults allogeneic analysis antigen asparaginase associated B-ALL B-lineage blasts Blood BrIHaematol Burkitt Burkitt lymphoma chemotherapy childhood acute lymphoblastic childhood leukemia children with acute chromosome chronic classification Clin Oncol clinical clonal cytarabine cytogenetic cytoplasmic defined deletion detected diagnosis differentiation disease dose drug encoding factor findings first FLT3 fusion gene expression gene rearrangements genetic genomic germline Hematol hematologic hematopoietic HSCT identified imatinib IMML immunophenotype induce inhibitors juvenile myelomonocytic leukemia leukemic cells lineage lymphocytic lymphoid lymphoma malignancies megakaryocytic mercaptopurine methotrexate methylation molecular monocytic mutations myelodysplastic syndrome Natl Acad Sci ofthe oncogene Oncology Group outcome pathway patients phenotype platelet polymorphisms precursor Proc Natl Acad profiling prognostic protein Pui CH receptor relapse remission risk significance specific stem cell subtypes survival T-ALL T-cell target therapy tion transcription translocation treatment trial tumor