Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA

Portada
CRC Press, 24 ene. 1997 - 352 páginas
The analysis of DNA sequence polymorphisms and mutations is of central importance in understanding biological systems. This book is devoted to the experimental analysis of DNA and presents easy-to-follow protocols. Various techniques from the simple to the highly complex are detailed in this volume, providing a wide spectrum of available methods and practical advice. The methods are described in terms of:
  • History and background
  • Principles and theory
  • Equipment and reagents
  • Protocols
  • Troubleshooting
  • Applications
  • Improvements
  • Results
  • Comparisons with other methods
  • Future prospects and developments
    This is an essential manual for researchers working in human, animal, or plant molecular genetics and is particularly valuable for hospital and commercial laboratories.
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    Índice

    Introduction G R Taylor
    1
    Direct Sequencing of Polymerase Chain Reaction Products
    163
    Heterozygote Determination Ising Automated
    175
    A Robust Radioactive Sequencing Protocol
    191
    MutSExonuclease Protection for the Detection
    207
    Enzyme Mismatch CleavageBacteriophage Resolvases
    217
    Chemical Cleavage of Mismatch in Heteroduplexes
    225
    Comparison of Mutation Detection by Chemical Cleavage
    237
    Analysis of DNA Sequence Ising Biosensors
    253
    Repeat Expansion Detection
    263
    Comparative Genomic Hybridization
    273
    Microplate Array
    287
    DNA Sequence Database Searches Comparisons
    307
    The Human Genome Database
    317
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    Sobre el autor (1997)

    Taylor\, Graham R.

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