Neural Repair, Transplantation, and Rehabilitation
This book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as Parkinson's and Huntington's, which are discussed in detail. The book then goes on to discuss newer cellular strategies involving the manipulation of neural cells both in culture and genetically, an approach that may ultimately be employed in the clinical situation.
Neural Repair, Transplantation and Rehabilitation is unique in bridging the gap from experimental studies to clinical trials, whilst also providing the non-specialist with a background in rehabilitation strategies as well as basic neuroscience. It is recommended for all those involved in the management of patients with degenerative and traumatic injuries to the nervous system.
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Spontaneous recovery after CNS damage
Immunological factors in graft survival
Chapter Four Nigral grafts in animal models of Parkinsons disease
Functional analysis of nigral grafts
Clinical trials of adrenal medulla transplants
Motor neurone disease
Chapter Nine Other sources of cells for transplantation
Ex vivo gene transfer
Rehabilitation of transplant patients?
Otras ediciones - Ver todo
acid adrenal medulla adult Alzheimer's disease animals astrocytes axons basal ganglia behavioural Björklund Brain Research brainstem catecholamines caudate nucleus cell death cell lines cellular Chapter cholinergic chromaffin cells clinical trials contralateral cortex cortical damage deficits dementia donor dopamine neurones dopaminergic dopaminergic neurones drug Dunnett effects embryonic experimental fibre fibroblast forebrain functional recovery gene transfer glial cells glutamate graft survival growth factor hippocampus host brain human Huntington's disease immunological impaired implantation induced injection injury innervation inputs intracerebral L-dopa molecules motor neurones MPTP neocortex neostriatum nervous system neural transplantation neurodegenerative Neurology Neuroscience neurotransmitter neurotrophic factor nigral grafts nigrostriatal normal oligodendrocytes Parkinson's disease pathway patients peripheral nerve phenotype precursor cells protein putamen rats re-innervation receptor regeneration repair response rotation Schwann cells septal spinal cord strategies striatal grafts striatal lesions striatum studies substantia nigra synaptic target techniques therapy tion treatment trophic ventral vivo
Página 260 - S., Johnson-Wood, K., Khan, K., Lee, M., Leibowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B.
Página 259 - Freed, CR, Breeze, RE, Rosenberg, NL, Schneck, SA, Wells, TH, Barrett, JN, Grafton, ST, Huang, SC, Eidelberg, D., Rottenberg, DA Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 year.
Página 250 - Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord inJury. Results of the Third National Acute Spinal Cord InJury Randomized Controlled Trial.