Neural Repair, Transplantation, and Rehabilitation

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Psychology Press, 1999 - 339 páginas
This book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as Parkinson's and Huntington's, which are discussed in detail. The book then goes on to discuss newer cellular strategies involving the manipulation of neural cells both in culture and genetically, an approach that may ultimately be employed in the clinical situation.
Neural Repair, Transplantation and Rehabilitation is unique in bridging the gap from experimental studies to clinical trials, whilst also providing the non-specialist with a background in rehabilitation strategies as well as basic neuroscience. It is recommended for all those involved in the management of patients with degenerative and traumatic injuries to the nervous system.
 

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Índice

Spontaneous recovery after CNS damage
17
Summary
31
Neural transplantation
48
Immunological factors in graft survival
62
Chapter Four Nigral grafts in animal models of Parkinsons disease
67
Functional analysis of nigral grafts
84
Clinical trials of adrenal medulla transplants
105
Summary
131
Motor neurone disease
189
Chapter Nine Other sources of cells for transplantation
203
Ex vivo gene transfer
220
Encapsulation
230
Environment
236
Rehabilitation of transplant patients?
244
Glossary
285
Abbreviations
303

Clinical applications of striatal grafts in HD
152
Models of trophic factor deficiency
166

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Página 260 - S., Johnson-Wood, K., Khan, K., Lee, M., Leibowitz, P., Lieberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Paganini, L., Penniman, E., Power, M., Schenk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B.
Página 260 - Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F...
Página 259 - Freed, CR, Breeze, RE, Rosenberg, NL, Schneck, SA, Wells, TH, Barrett, JN, Grafton, ST, Huang, SC, Eidelberg, D., Rottenberg, DA Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 year.
Página 250 - Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord inJury. Results of the Third National Acute Spinal Cord InJury Randomized Controlled Trial.
Página 253 - Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release.

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