T Cells in Arthritis

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P. Miossec, W. van den Berg, G. Firestein
Springer Science & Business Media, 21 jul 1998 - 236 páginas
Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.
 

Índice

T cells as secondary players in rheumatoid arthritis
1
T cell receptor rearrangements in arthritis
19
T cellindependent joint destruction
55
Lessons from animal models
75
The TH1TH2 cytokine balance in arthritis
93
Interactions between T cell plasma membranes and monocytes
111
Control of T cell migration into the synovium
129
T cell reactivity to EpsteinBarr virus in rheumatoid arthritis
149
T cell responses in reactive and Lyme arthritis
169
T cell directed therapies and biologies
189
T Cells as primary players in rheumatoid arthritis
201
Index
233
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