T Cells in ArthritisP. Miossec, W. van den Berg, G. Firestein Springer Science & Business Media, 21 jul 1998 - 236 páginas Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells. |
Índice
T cells as secondary players in rheumatoid arthritis | 1 |
T cell receptor rearrangements in arthritis | 19 |
T cellindependent joint destruction | 55 |
Lessons from animal models | 75 |
The TH1TH2 cytokine balance in arthritis | 93 |
Interactions between T cell plasma membranes and monocytes | 111 |
Control of T cell migration into the synovium | 129 |
T cell reactivity to EpsteinBarr virus in rheumatoid arthritis | 149 |
T cell responses in reactive and Lyme arthritis | 169 |
T cell directed therapies and biologies | 189 |
T Cells as primary players in rheumatoid arthritis | 201 |
233 | |
Otras ediciones - Ver todo
T Cells in Arthritis P. Miossec,W. van den Berg,G. Firestein No hay ninguna vista previa disponible - 2014 |
T Cells in Arthritis P. Miossec,W. van den Berg,G. Firestein No hay ninguna vista previa disponible - 2012 |
Términos y frases comunes
Acad Sci USA activation adhesion molecules adhesion receptors alleles antigen antigen-specific apoptosis arthri Arthritis Rheum 40 arthritogenic associated autoimmune bacterial binding cartilage CD4-mAb CD4+ T cells CD8+ CDR3 cell clones cell receptor cell response cell subsets chemokines Clin Exp Immunol Clin Invest collagen cytokines Dayer JM detected disease endothelial cells epitope expression fibroblast-like fibroblasts gene human IFNy immune response induce infiltration inflammation inflammatory interactions interleukin joint destruction Lyme arthritis lymphocytes macrophages mediated Miossec MMPs monoclonal antibody monocytes Natl Acad Sci oligoclonal pathogenesis pathogenic patients with rheumatoid peptide peripheral blood phenotype polymorphism Proc Natl Acad production proliferation protein RA patients RA PB RA synovial RA synovium reactive arthritis Rheum 39 rheumatoid synovial Rheumatol role sequence shared epitope Sieper specific stimulated studies superantigen susceptibility synovial fibroblasts synovial fluid synovial T cells synovial tissue synoviocytes synovium T-cell TCR repertoire tion transendothelial migration Vẞ
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