New Molecular Targets for Cancer ChemotherapyCRC Press, 27 jun 1994 - 236 páginas This book covers a wide range of novel biochemical targets that appear to be the best leads in terms of designing novel targets for anticancer drug design. New Molecular Targets for Cancer Chemotherapy is a unique, multi-disciplinary effort, with internationally respected authors from the fields of growth factor-receptor interaction, phosphoinositide and phospholipase signal transduction, and DNA-drug binding interactions. The science is placed in clinical context and illustrations explain how clinicians can incorporate a mechanistic, pharmacodynamic approach into early clinical trial design. |
Índice
Chapter | 1 |
An Overview of the Regulation of PhospholipaseLinked Cell Signaling | 31 |
Growth Factor Receptors as Targets | 45 |
Protein Tyrosine Kinase Inhibitors | 67 |
Chapter 5 | 81 |
Chapter 6 | 97 |
Chapter 7 | 121 |
Apoptosis as a Target for Cancer Chemotherapy | 143 |
Chapter 9 | 159 |
Chapter 10 | 177 |
Chapter 11 | 195 |
| 213 | |
Términos y frases comunes
3H]vinblastine 3T3 cells Acad agents amino acids analogues antibodies antisense antitumor apoptosis binding Biochem Biol blockers bombesin c-erbB2 Ca2+ cancer cells Cancer Res carcinoma cell cycle cell death cell lines cellular Chem clinical trials compounds cytotoxic diacylglycerol differentiation domain dose effects EGF receptor EGFR endonuclease enzyme epidermal growth factor expression fibroblasts function growth factor receptor human hydrolysis increase induced inhibition inhibitors inositol interaction intracellular involved isoforms leukemia ligand lipid malignant MAP kinase membrane mitogenic molecular molecule mutation Natl normal nucleotide oligonucleotides oncogene overexpression P-gp PDGF phase phenotype phorbol esters phosphatidylinositol phospholipase phosphorylation PKC activity potential Proc protein kinase proto-oncogene PtdIns PtdInsPLC Ras proteins regulation response role sequence signal transduction signaling pathways specific staurosporine stimulation structure studies substrate suppressor genes Swiss 3T3 synthesis target therapeutic therapy toxicity transcription factors transformation tumor cells tumor suppressor genes tyrosine phosphorylation tyrphostins vitro wild-type
Referencias a este libro
Novel Anticancer Agents: Strategies for Discovery and Clinical ..., Número 937 Alex A. Adjei,John K. Buolamwini No hay ninguna vista previa disponible - 2006 |