Calpains: Pharmacology and Toxicology of a Cellular Protease

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K K W Wang, Po-wai Yuen
CRC Press, 17 jun. 1999 - 448 páginas
This new edition offers a clear and through examination of the most recent results of thirty years of research on calcium-activated-neutral protease (CANP or Calpain). Coverage includes the implications of the recently gained ability to produce functionally active recombinant calpain in various human disorders such as cerebal ischemia, traumatic brain and spinal cord injury, cataract formation, myocardial infarction, and Alzheimer's disease. The resulting research to find more selective calpain inhibitors is also discussed. With a copy of Calpain: Pharmacology and Toxicology of Calcium Dependent Protease you will better understand why the calpain research area is such an exciting and promising one.
 

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Índice

Structure of Calpastatin and Its Inhibitory Control of Calpain
25
Expression of Calpain in Bacteria and in Insect Cells
51
Structure and Assembly of the CalciumBinding Domains
63
Calpain Substrates Assay Methods Regulation and Its Inhibitory
77
Calpain in Signal Transduction
103
The Calpain System in Muscle Tissue
127
Involvement of Calpains in Cell Cycle G1 to SPhase
161
Calpain in Excitotoxicity Cerebral Ischemia and Neuronal
179
Calpain and Cerebrovascular Injury
251
Calpains in the Pathogenesis of Alzheimers Disease
267
Calpain and Apoptosis in the Immune System
293
The Role of Calpain in Renal Proximal Tubular and Hepatocyte
307
Calpains in the Lens of the Eye
331
Calpain Activation and Expression in Toxicant Injury
349
Calpain 3 p94 in LimbGirdle Muscular Dystrophy Type 2A
369
Genetic Analysis of Calpain Isoform Function in Skeletal
391

The Contribution of Calpain Proteolysis to Neuronal Death
191
The Pathophysiological Role of Calpain in Spinal Cord Injury
211
CalpainMediated Proteolysis of Neuronal Structural Proteins
229
Crustacean CalciumDependent Proteinases
409
Structure
429
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