Bile Acids and PregnancyPregnancy represents an allograft in so far that half of the antigens are foreign to the mother. Therefore, a bidirectional interaction between the maternal and the fetal immune systems must exist, which could be disturbed by preexisting autoimmune liver diseases. Since nowadays autoimmune liver diseases are increasingly detected as early stage diseases due to modern diagnostic procedures, e.g. in women of childbearing age, and since the number of posttransplant pregnancies has become an issue due to improved survival, questions concerning regnancy, autoimmune liver disease and treatment options with bile acids and/or immunosuppressants are of an ever-increasing interest. This book, the proceedings of a Falk Workshop held in Freiburg, Germany, on June 2, 2002, is certainly unable to give any definite answers to any of the hundreds of still remaining questions in this fascinating field, but hopefully it will help to stimulate and initiate cooperation among immunologists, bile acid researchers, gynaecologists and internists. |
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Índice
Introduction | 1 |
Immunology of pregnancy | 3 |
Intrinsic susceptibility of mouse trophoblasts to NKcellmediated attack in vivo | 5 |
Induction of immunological tolerance to fetal antigens during pregnancy | 6 |
The influence of pregnancy on cytokine production | 17 |
MHC expression in the human placenta and role of HLAG | 18 |
Ten ways to suppress the maternal immune system | 20 |
Pregnancy liver disease and bile acids | 27 |
Ursodeoxycholic acid therapy in intrahepatic cholestasis of pregnancy clinical results | 36 |
Pregnancy and hepatic transport implications for the pathogenesis of intrahepatic cholestasis of pregnancy | 39 |
The influence of ursodeoxycholic acid and maternal cholestasis on bile acid transport across the placenta | 46 |
Effects of highdose UDCA on bile acid metabolism of newborns and mothers with cholestasis of pregnancy | 53 |
Immune modulation by cholestasis and bile acids | 57 |
Ursodeoxycholic acid in the treatment of primary biliary cirrhosis and primary sclerosing cholangitis in pregnancy | 70 |
Final remarks | 75 |
| 77 | |
Ursodeoxycholic acid therapy and progesterone in intrahepatic cholestasis of pregnancy | 29 |
Términos y frases comunes
activity allogeneic alterations amount associated bile acids bile salts blood canalicular CDCA changes cholestasis of pregnancy cholestatic circulation Class clinical compared concentration conjugated cytokines decrease delivery dose downregulation encounter et al explain expression Falk Symposium fetal antigens fetus Figure function gene groups hepatic Hepatobiliary Hepatol Hepatology HLA-G human immune response immune system Immunol immunological immunosuppressive improve increased induced Inflammatory Bowel Diseases inhibition inhibitory effect intrahepatic cholestasis involved ISBN leads levels liver diseases lymphocytes maternal immune maternal T cells mechanisms membrane metabolites mice molecular molecules mother observed occurs organic patients peripheral placenta potential present production progesterone protein pruritus receptor reduced Reference regulation rejection reported response Reyes H role secretion serum shown significant similar specific suggest tests therapy tion tissue tolerance transgenic transport treated treatment trophoblast UDCA umol/L ursodeoxycholic acid values weeks women
Referencias a este libro
Cholestatic Liver Diseases: Therapeutic Options and Perspectives: In honour ... U. Leuschner,U. Broomé,A. Stiehl No hay ninguna vista previa disponible - 2004 |
Información bibliográfica
| Título | Bile Acids and Pregnancy Volumen 129,Parte 1 de Falk Symposium |
| Editores | U. Leuschner, P.A. Berg, J. Holtmeier |
| Edición | ilustrada |
| Editor | Springer Science & Business Media, 2002 |
| ISBN | 0792387821, 9780792387824 |
| N.º de páginas | 96 páginas |
| Exportar cita | BiBTeX EndNote RefMan |