Stress-Inducible Cellular ResponsesU. Feige, R.I. Morimoto, Barbara Polla Birkhäuser, 11 mar 2013 - 495 páginas This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimetal approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. The book will be invaluable for all those working on stress and is intended for every "stress laboratory" as a source of knowledge and perspectives. |
Índice
Roles for hsp70 in protein translocation across membranes | 25 |
J Wei and L M Hendershot | 41 |
Sherman and A L Goldberg | 57 |
W B Pratt U Gehring and D O Toft | 79 |
Luz and W J Lennarz | 96 |
Morimoto | 119 |
Morimoto P E Kroeger and J J Cotto | 138 |
T Yura K Nagahigashi and M Kanemori | 165 |
Mammalian DNA repair responses and genomic instability | 289 |
Z Zhu and D J Thiele | 307 |
G H W Wong R L Kaspar and G Vehar | 321 |
U Feige | 335 |
U Feige and W van Eden | 359 |
B S Polla and A Cossarizza | 376 |
A Y C Liu Y K Lee D Manalo and L E Huang | 393 |
Yahara | 410 |
T A Rouault and R D Klausner | 182 |
O Bensaude S Bellier M F Dubois F Giannoni | 199 |
H Shinagawa | 220 |
B S Polla | 237 |
Tyrrell | 255 |
N J Holbrook Y Liu and A J Fornace | 272 |
Li and A Nussenzweig | 425 |
K Suzue and R A Young | 450 |
K Nagata | 467 |
B S Polla | 482 |
Otras ediciones - Ver todo
Stress-Inducible Cellular Responses U. Feige,R.I. Morimoto,Barbara Polla Vista previa restringida - 1996 |
Stress-Inducible Cellular Responses U. Feige,R.I. Morimoto,Barbara Polla No hay ninguna vista previa disponible - 2011 |
Stress-Inducible Cellular Responses U. Feige,R. I. Morimoto,Barbara Polla No hay ninguna vista previa disponible - 2014 |
Términos y frases comunes
Acad aconitase antigen apoptosis Biochem Biol biomarkers calnexin cell lines cellular Chem Cloning complex cytosolic degradation DNA binding DNA damage DNA repair DnaJ DnaK domain EMBO encoding enzyme Escherichia coli eukaryotic Feige fibroblasts function gene expression GroEL GrpE heat shock factor heat shock genes heat shock protein heat shock response heat shock transcription homologous HSF1 hsp70 gene hsp70 proteins human hsp70 immune increased induced infection inhibition interaction involved levels mammalian cells MAP kinase mechanism mediated membrane mitochondrial MnSOD molecular chaperones mRNA mutant Natl overexpression oxidative stress pathway peptide phosphorylation Polla polymerase polypeptides Proc promoter protease protective protein disulfide isomerase protein folding protein kinase protein synthesis quercetin radiation RecA receptor regulation regulatory replication role sequence signal specific steroid stress proteins stress response studies substrate subunit temperature thermotolerance tion transcription factor transcriptional activation translocation ubiquitination virus vitro vivo yeast