Fundamentals of Genetic Epidemiology, Volumen 22;Volumen 1993Oxford University Press, 1993 - 383 páginas With continued progress in mapping and sequencing of the human genome, and increasing recognition of the role of genes in disease etiology, there is a need for a more sophisticated approach to the investigation of the causes of complex chronic diseases. This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease etiology. After a brief historical overview of genetics and epidemiology and their gradual rapprochement, the authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations. They describe fundamental research strategies of genetic epidemiology including population and family studies. Among the former are the study of the distribution of genetic traits and the role of nonspecific genetic indicators (such as inbreeding and admixture) in the occurrence of diseases. Among the latter are the analysis of familial aggregation of disease and its causes by epidemiologic methods as well as techniques of formal genetic analysis (variance components, segregation and linkage analysis). Finally, the authors discuss the increasing applications of genetic epidemiology in preventive medicine, public health surveillance, and the emerging ethical issues regarding use of genetic information in society. |
Índice
Section 1 Background and Fundamentals | 3 |
Section 2 Population Studies | 82 |
Section 3 Family Studies | 164 |
Section 4 Applications | 312 |
References | 340 |
379 | |
Otras ediciones - Ver todo
Fundamentals of Genetic Epidemiology, Volumen 22;Volumen 1993 Muin J. Khoury,Terri H. Beaty,Bernice H. Cohen Vista de fragmentos - 1993 |
Fundamentals of Genetic Epidemiology, Volumen 22;Volumen 1993 Muin J. Khoury,Terri H. Beaty,Bernice H. Cohen No hay ninguna vista previa disponible - 1993 |
Términos y frases comunes
affected individuals allele frequencies American Journal approach ascertainment association attributable fraction autosomal dominant autosomal recessive biologic birth defects case-control study cell chromosome clinical coefficients cohort study confounding controls correlation covariates disease frequency disease risk disorders distribution environmental factors epidemiologic studies estimate etiologic etiologic heterogeneity example exposure familial aggregation family data family history family studies gene product genetic and environmental genetic epidemiology genetic factors genetic markers genetic traits genotype haplotypes heritability heterozygote Human Genetics identify inbreeding interaction Khoury likelihood function Lilienfeld linkage analysis loci marker locus maternal age mating measure Mendelian methods model of inheritance mutation rates nongenetic normal null hypothesis observed occur odds ratio offspring outcomes pairs parameters parents pedigrees phenotype polygenic polymorphic population prevalence probability proband regression relative risk risk factors sample segregation analysis sibs sibships single-locus specific statistical susceptibility syndrome Table transmission trisomy 21 twins type I error variables variance variation