DNA Repair and MutagenesisErrol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood American Society for Microbiology Press, 22 nov 2005 - 1118 páginas An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage. |
Índice
PART 1 | |
DNA Damage | |
Synthesis | |
Introduction to Mutagenesis | |
PART 2 | |
Reversal of Alkylation Damage in | |
Teleological Considerations Concerning the Reversal of Alkylation Base | |
Summary and Conclusions | |
Base Excision Repair | |
Otras ediciones - Ver todo
DNA Repair and Mutagenesis Errol C. Friedberg,Graham C. Walker,Wolfram Siede Vista de fragmentos - 1995 |
Términos y frases comunes
Acad activity Adapted from reference adducts alkylating agents amino acid AP endonuclease base damage base pairs binding Biochem Biochemistry Biol C-terminal Cancer catalytic chapter Chem chromatin complex cross-links crystal structure cytosine damaged DNA deamination defective DNA damage DNA glycosylase DNA ligase DNA polymerase DNA repair DNA replication DNA strand DNA synthesis DNA-binding domain double-stranded E. C. Friedberg EMBO encodes endonuclease enzyme Escherichia coli eukaryotic formation function gene genetic genome guanine homolog human cells incision interactions irradiation lesions mammalian cells mechanism methyl mismatch molecular mutagenesis mutagenic mutations Natl nuclease Nucleic Acids Res nucleosome nucleotide excision repair oxidative P. C. Hanawalt pathway PD-DNA photolyase photolyase photoproducts Proc protein pyrimidine dimers RAD3 reaction recombination repair synthesis residues RNAPII Saccharomyces cerevisiae Sancar sequence specific strand breaks substrate subunit TFIIH thymine transcription uracil UV radiation UvrA UvrB protein UvrC vitro vivo xeroderma pigmentosum yeast