Clinical ImmunotoxicologyDavid S Newcombe CRC Press, 30 jun 1992 - 450 páginas This text is a comprehensive source of information on the toxic effects of environmental, industrial, and pharmacological agents on the human immune system. Focusing entirely on human immunotoxicology, without relying on animal models, the book explains the basic principles of immunotoxicology defines the mechanisms by which immunotoxins act, describes the clinical expression of immunotoxic disorders in the lung, skin, and other target organs, offers practical guidelines for early detection and control of host defense dysfunctions, and explores strategies for assessing the short- and long-term health effects of new and old chemicals and biologicals. The book includes extensive discussions on the role of low-dose, chronic immunosuppression in cancer, as well as on specific environmental and occupational immunotoxins and immunotoxic drugs used in hematology, anesthesiology, oncology and transplantation surgery. |
Índice
Immunotoxicology A New Challenge | 1 |
The Immunological Assessment of Immunotoxic Effects in Man | 9 |
The Immune System An Appropriate and Specific Target for Toxic Chemicals | 27 |
Flow Cytometric Analysis of the Immune and Phagocytic Cells | 43 |
An Approach for Analyzing the Role of Mast Cells in Immunotoxicological Processes and Other Biological Responses | 49 |
Toxicity of Monoclonal Antibodies and Conjugates | 83 |
The Immunotoxicology of Cytokines | 93 |
Immunopathogenesis of the Acquired Immune Deficiency Syndrome Relevance to Immunotoxicity | 109 |
Selective Interactions of Cancer Chemotherapeutic Agents with the Host Immune System | 177 |
Pulmonary Hypersensitivity Disorders | 191 |
The Immunopathogenesis of Pulmonary Responses to Environmental and Chemical Pollutants | 203 |
Bronchoalveolar Lavage and Bronchial Reactivity in Humans Associated with Environmental and Chemical Exposures | 277 |
Recent Studies of the Human Immunotoxic Effects of 2378TetrachlorodibenzopDioxin | 339 |
Immunotoxicity of Organophosphorus Compounds | 349 |
Environmental Chemicals with Immunotoxic Properties | 365 |
Metalinduced Alterations of Immunity | 401 |
Cyclosporine Lessons from a Useful Immunosuppressant | 125 |
Druginduced Immunological Disorders of the Blood | 141 |
Halothane Hepatitis A Possible Immunemediated Hepatitis | 155 |
The Immunology of Contact Dermatitis | 421 |
433 | |