Oncogenomics: Molecular Approaches to Cancer

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Charles Brenner, David Duggan
John Wiley & Sons, 19 nov. 2004 - 400 páginas
This book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets.
 

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Índice

DNA RNA AND PROTEIN
15
Section III MODEL SYSTEMS
185
Section IV MOLECULARLY TARGETED DRUGS
291
Section V CONCLUSION
359
INDEX
365
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Sobre el autor (2004)

Charles Brenner is Director of the Cancer Mechanisms Program at Dartmouth's Norris Cotton Cancer Center in New Hampshire. He trained in yeast molecular biology with Anthony Brake at Chiron and yeast genetics with Kunihiro Matsumoto at DNAX before earning his Ph.D. in the biochemistry department at Stanford with Robert Fuller. In 1993, as a Leukemia Society Fellow, Brenner moved to Brandeis to train in X-ray crystallography with Gregory Petsko and Dagmar Ringe and then took an independent position at the Kimmel Cancer Center at Jefferson in 1996. Brenner rose to head the KCC's Program in Structural Biology and Bioinformatics in 2000 and joined Dartmouth Medical School's faculties of Genetics and Biochemistry in 2003. Dr. Brenner's research group uses genetics, enzymology and X-ray crystallography to dissect the cellular pathways perturbed by loss of the FHIT tumor suppressor gene, which is lost early in the development of many tumors of epithelial origin.

David Duggan received his Ph.D. in 1997 in Human Genetics at Pittsburgh and trained with Jeffrey Trent in microarray analysis of breast and prostate cancer from 1998 to 2000 at the National Human Genome Research Institute. Duggan then served as an associate investigator at the National Institute of Arthritis and Musculoskeletal and Skin Diseases until 2003 when he took his current position at the Translational Genomics Research Institute in Arizona. Dr. Duggan's laboratory uses SNP genotyping and microarray analysis to investigate the genetic basis of human diseases.

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