Molecular Chaperones and Cell Signalling
This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?
Comentarios de usuarios - Escribir una reseña
No hemos encontrado ninguna reseña en los sitios habituales.
Changing Paradigms of Protein Trafficking and Protein Function
Extracellular Biology of Molecular Chaperones Molecular Chaperones as Cell Regulators
Extracellular Biology of Molecular Chaperones Physiological and Pathophysiological Signals
Extracellular Biology of Molecular Chaperones Molecular Chaperones as Therapeutics
Otras ediciones - Ver todo
Acad Sci USA activity adaptive immune adjuvant anti-inﬂammatory antibodies antigen apoptosis arthritis autoimmune bacterial binding Biochem Biol Chem Brenneman cancer CD4+ T cells CD8+ Cell Biol cell responses cell surface cellular chaperonin Chapter clones complex cytokine cytosol dendritic cells diabetes disease early pregnancy factor enzyme exogenous expression extracellular ﬁndings ﬁrst function gene Gozes GroEL heat shock factor heat shock protein human identiﬁed immune responses immune system immunisation Immunol induce inﬂammation inﬂammatory inhibit inhibitor innate immune interactions involved kinase leaderless levels ligand lymphocytes macrophages maturation mechanism mediated membrane mice mitochondria molecular chaperones molecules monocytes moonlighting proteins mycobacterial Natl Acad Sci neuroprotective peptide pro-inﬂammatory Proc Natl Acad protein 70 protein folding regulation regulatory release role secretion secretory shock protein 60 shock protein gp96 signiﬁcant speciﬁc Srivastava stimulation stress proteins studies tein tion tissue TLR2 TLR4 TLRs Toll-like receptor transcription factor vitro