Molecular Chaperones and Cell SignallingBrian Henderson, A. Graham Pockley Cambridge University Press, 18 jul 2005 This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones? |
Índice
Intracellular Disposition of Mitochondrial Molecular | 22 |
CHANGING PARADIGMS OF PROTEIN TRAFFICKING | 43 |
Proteins with Multiple Functions | 61 |
The Unorthodox View | 78 |
EXTRACELLULAR BIOLOGY OF MOLECULAR | 97 |
TollLike ReceptorDependent Activation of Antigen | 113 |
Regulation of Signal Transduction by Intracellular | 133 |
Heat Shock Proteins Their Cell Surface Receptors and Effect | 160 |
Hsp27 as an Antiinflammatory Protein | 220 |
BiP a Negative Regulator Involved in Rheumatoid Arthritis | 234 |
EXTRACELLULAR BIOLOGY OF MOLECULAR | 249 |
Heat Shock Proteins Regulate Inflammation by Both | 263 |
A Platform for the Induction | 288 |
Molecular Chaperones as Inducers of Tumour Immunity | 300 |
EXTRACELLULAR BIOLOGY OF MOLECULAR | 319 |
| 327 | |
Molecular ChaperoneCytokine Interactions at | 179 |
EXTRACELLULAR BIOLOGY OF MOLECULAR | 193 |
Otras ediciones - Ver todo
Molecular Chaperones and Cell Signalling Brian Henderson,A. Graham Pockley No hay ninguna vista previa disponible - 2011 |
Molecular Chaperones and Cell Signalling Brian Henderson,A. Graham Pockley No hay ninguna vista previa disponible - 2005 |
Términos y frases comunes
Acad Sci USA activity adaptive immune adjuvant anti-inflammatory antibodies antigen apoptosis apoptotic arthritis autoimmune bacterial binding Biochem Biol Chem cancer CD4+ T cells CD8+ Cell Biol cell responses cell surface cell types cellular chaperonin Chapter clones complex cytokine cytosol dendritic cells diabetes disease early pregnancy factor endogenous enzyme eukaryotic exogenous expression extracellular function gene Gozes GroEL heat shock factor heat shock protein human immune responses immune system immunisation Immunol induce inflammation inflammatory inhibit inhibitor innate immune interaction involved kinase leaderless levels ligand lymphocytes macrophages maturation mechanism mediated membrane mice mitochondria molecular chaperones molecules monocytes moonlighting proteins mycobacterial Natl Acad Sci neuroprotective peptide plasma pro-inflammatory Proc Natl Acad protein folding regulation regulatory release role secretion secretory sequence serum shock protein 70 shock protein gp96 specific Srivastava stimulation studies tein tion tissue TLR2 TLR4 TLRs Toll-like receptor tumour cells vitro vivo