Radiopharmaceuticals for Positron Emission Tomography - Methodological AspectsG. Stöcklin, V.W. Pike Springer Science & Business Media, 30 jun 1993 - 180 páginas Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today. This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here. |
Índice
PET RADIONUCLIDE PRODUCTION | 1 |
RADIOCHEMISTRY AUTOMATION FOR PET | 45 |
QUALITY ASSURANCE AND QUALITY CONTROL OF SHORTLIVED RADIOPHARMACEUTICALS FOR PET | 91 |
PET RADIOPHARMACEUTICAL METABOLISM PLASMA METABOLITE ANALYSIS | 151 |
Otras ediciones - Ver todo
Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects G. Stöcklin,V.W. Pike Vista previa restringida - 2012 |
Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects G. Stocklin,V. W. Pike No hay ninguna vista previa disponible - 2014 |
Radiopharmaceuticals for Positron Emission Tomography - Methodological Aspects G. Stöcklin,V.W. Pike No hay ninguna vista previa disponible - 2010 |
Términos y frases comunes
11C-labelled 11C]carbon dioxide 11C]iodomethane 13N]ammonia 180-enriched water 18F]fluoride Abstract acetonitrile acid analysis Appl automated batch benzodiazepine butyrophenone carbon chemical purity chromatography Clark J.C. clinical Coenen H.H. column Comar Compd compounds containing Crouzel cyclotron detector dopamine eluted Excitation functions flumazenil fluorine fluorine-18 Fowler J.S. Grignard reagent Guillaume Halldin Hammersmith Hospital HPLC injection irradiation Isot isotonicity Jülich labelled Långström Limulus test Luxen Mazière measurement metabolism metabolites methanol method monoxide N-methyl-11C]flumazenil nitrogen nitrogen-13 no-carrier-added Nucl nuclear nucleophilic nucleophilic substitution operated oxygen parameters PET studies Pharmaceutical quality phase Pike V.W. plasma positron emission tomography positron-emitters precursor preparation pressure procedures protein proton purification quality control Radiat radiochemical purity radiochemical yield radioligand radionuclidic purity Radiopharm radiopharmaceutical radiosynthesis reaction receptor robot routine production samples short-lived radiopharmaceuticals solution solvent specific radioactivity spiperone stainless steel sterilised Stöcklin G synthesis target gas Teflon tests tubing Vaalburg valves vial vivo Wolf A.P.
Pasajes populares
Página 173 - Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging.
Página 174 - SO and Gawell L. (1985) Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain.
Página 172 - G: Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 1988; 45:71-76 14.
Referencias a este libro
Isotope Production and Applications in the 21st Century: Proceedings of the ... Nigel R. Stevenson,TRIUMF. Vista previa restringida - 2000 |