A Perinatal Strategy For Preventing Adult Disease: The Role Of Long-Chain Polyunsaturated Fatty Acids: The Role of Long-Chain Polyunsaturated Fatty AcidsSpringer Science & Business Media, 31 may 2002 - 192 páginas Obesity, type 2 diabetes mellitus, hypertension, and coronary heart disease are serious diseases affecting asignificantnumberofadults across the globe. Insulin resistance, low-grade systemic inflammation, low-birth weight, maternalproteinmalnutrition, neonatalhighcarbohydratediet, and high fat diet are associated with these diseases. On the other hand, adequatelybreast-fedsubjects are substantially at lowerrisk. Ifso, whatis the linkbetweenthese variousfactors?Onepossibilityisthat humanbreast milk containsfactorsthatconferresistancetothese modemdiseases.Here I present arguments that long-chain polyunsaturated fatty acids (LCPUFAs) presentinthebreastmilkcouldberesponsibleforthisbeneficialaction. Though the entire class of LCPUFAs provided dunng perinatal periodislikelytohavearole inthepreventionofadultdiseases, itshouldbe understoodthateachofthese LCPUFAsexhibitauniqueand insome cases opposing bioactive properties.It is important to note that there is a close interaction between (0-6 and (0-3 fatty acids. Human breast rmlk contains almost twice (0.78 vs 0.43 %w/w)the amountof(0-6LCPUFAs (gamma- linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid) comparedto (0-3LCPUFAs(eicosapentaenoicacid, docosapentaenoicacid, and docosahexaenoic acid). Obviously, the best would be to mimic the composition/concentrations in which these fatty acids are present in the breastmilk. The conceptthat LCPUFAs given duringpennatalperiod(and inadultlife)isbeneficialinpreventingadultdiseasescertainlyneedsfurther exploration.Iamconfidentthat someofthe enterprisingreaderswill delve intothepossibilitiessuggestedafterreadingthisbook. UndurtiN.Das, M.D., FAMS. To MyWifeLakshmi and Mytwoeyes DaughterArundhatiandSonAditya Chapter #1 Introduction Fetal/Perinatalimprintingonlaterlife It isbelievedthat stimuliormsults during criticalorsensitiveperiods inearlylifecanhave lifetimeconsequences.Thisconceptiswellestablished in developmental biology and has been termed "programming". The evidence for programming confirmed the critical period for imprinting in animals, more so in birds'. Programming stimuli may be generated endogenously, such as hormonal signals', or they may be environmental. |
Índice
Introduction | 1 |
Perinatal origins of adult disease | 5 |
Perinatal origins of adult disease | 33 |
Perinatal origins of adult disease | 49 |
Perinatal origins of adult disease | 55 |
Metabolic Syndrome X and lowgrade systemic inflammation | 61 |
Longchain polyunsaturated fatty acids in adult diseases A hypothesis | 95 |
Breastfeeding Composition and benefits | 113 |
Longchain polyunsaturated fatty acids | 135 |
A perinatal strategy to prevent adult diseases The role of longchain polyunsaturated fatty acids Clinical implications and testing the hypothesis | 175 |
189 | |
Otras ediciones - Ver todo
A Perinatal Strategy For Preventing Adult Disease: The Role Of Long-Chain ... Undurti N. Das Vista previa restringida - 2011 |
A Perinatal Strategy For Preventing Adult Disease: The Role Of Long-Chain ... Undurti N. Das No hay ninguna vista previa disponible - 2012 |
A Perinatal Strategy for Preventing Adult Disease: The Role of Long-Chain ... Springer No hay ninguna vista previa disponible - 2012 |
Términos y frases comunes
action activity adipose tissue adult diseases alterations animals associated atherosclerosis Barker DJP Biol birth weight blood pressure brain breast milk breast-fed breast-feeding C-reactive protein cancer cardiovascular childhood cholesterol concentrations coronary heart disease cytokines decreased DGLA diabetes mellitus diet dietary docosahexaenoic acid dopamine effect eicosapentaenoic acid endothelial cells enhance enzymes essential fatty acids expression feeding fetal growth food intake function gene glucose tolerance Hales CN human milk hyperinsulinemia hypertension hypothalamus incidence increased induced infants inflammatory inhibit insulin receptors insulin resistance insulin sensitivity Lancet LCPUFAs leptin levels lipid long-chain polyunsaturated fatty low-grade systemic inflammation maternal membrane Metabolic Syndrome mice mRNA neurons neurotransmitters Nutr obesity offspring overweight perinatal period plasma glucose polyunsaturated fatty acids PPAR-y PPARS pregnancy prevent pro-inflammatory cytokines production Prostaglandins PUFAs rats regulation risk factors role serotonin serum suggests Syndrome X synthesis TNF-a tumor type 2 diabetes vitro women
Referencias a este libro
Nutrients, Stress and Medical Disorders Shlomo Yehuda,David I. Mostofsky Vista previa restringida - 2007 |