Evidence-based Laboratory Medicine: From Principles to Outcomes

acute coronary syndromes analysis assessment associated benefits bias cardiac chapter cholesterol Clin Chem clinical audit clinical practice clinical question clinicians Cochrane compared cost-effectiveness costs CRC screening criteria critically appraised D-dimer databases decision diabetes diagnostic odds ratio diagnostic studies diagnostic test disease economic evaluation effectiveness estimates evaluation of diagnostic evidence base Evidence-Based Laboratory Medicine evidence-based medicine example ferritin guidelines Guyatt GH Haynes RB HbA1c healthcare heterogeneity identified important improved index test intervention laboratory tests Lijmer likelihood ratios markers Medline meta-analysis methodological monitoring myocardial infarction negative odds ratio performance POCT population posttest probability pretest probability prostate cancer pulmonary embolism randomized controlled trials reference standard reference test relevant risk ROC curve Sackett DL sensitivity and specificity studies of diagnostic systematic reviews tacrolimus target disorder test accuracy test evaluation test results therapy threshold tion treatment troponin µg/L