Vogel and Motulsky's Human Genetics: Problems and Approaches
Friedrich Vogel, Gunter Vogel, Arno G. Motulsky, Departments of Medicine and Gerome Sciences Arno G Motulsky
Springer Science & Business Media, 1997 - 851 páginas
The fourth, completely revised edition of this classical reference and textbook presents a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics. In the 10 years since the appearance of the third edition, many new insights have emerged for understanding the genetic basis of development and function in human health and disease. Human genetics, with its emphasis on molecular concepts and techniques, has become a key discipline in medicine and the biomedical sciences.
The fourth edition has been extensively expanded by new chapters on hot topics such as epigenetics, pharmacogenetics, gene therapy, cloning and genetic epidemiology. In addition a section giving an overview on the main model organisms (mouse, canine, dog, worm, fly, yeast) used in human genetics research has been introduced.
This book will be of interest to human and medical geneticists, scientists in all biomedical sciences, physicians and epidemiologists, as well as to graduate and postgraduate students who desire to learn the fundamentals of this fascinating field.
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of Detrimental Mutations Impact of the Genetic Load Concept on Human
History of Human Genetics
of Genes and Formal Genetics
Modes of Inheritance
Description and Dynamics
Research Strategies and Examples
Symptoms Leading to the Detection of Enzyme Defects Clinical Diagnosis
Do Thyroid Autoantibodies and Autoimmune Disease Also Enhance
Somatic Mutation Cancer and Aging
Differences Between Populations
Genetic Counseling and Prenatal Diagnosis Human Genome
Genetic Manipulations and the Biological Future
Data Bases and Expert Systems
Heritability Estimates from Twin Data
Programs and Examples