Vogel and Motulsky's Human Genetics: Problems and Approaches

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The fourth, completely revised edition of this classical reference and textbook presents a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics. In the 10 years since the appearance of the third edition, many new insights have emerged for understanding the genetic basis of development and function in human health and disease. Human genetics, with its emphasis on molecular concepts and techniques, has become a key discipline in medicine and the biomedical sciences.

The fourth edition has been extensively expanded by new chapters on hot topics such as epigenetics, pharmacogenetics, gene therapy, cloning and genetic epidemiology. In addition a section giving an overview on the main model organisms (mouse, canine, dog, worm, fly, yeast) used in human genetics research has been introduced.

This book will be of interest to human and medical geneticists, scientists in all biomedical sciences, physicians and epidemiologists, as well as to graduate and postgraduate students who desire to learn the fundamentals of this fascinating field.

 

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Índice

of Detrimental Mutations Impact of the Genetic Load Concept on Human
1
History of Human Genetics
11
Chromosomes
25
3
53
Conclusions
79
of Genes and Formal Genetics
123
Modes of Inheritance
129
4
135
Description and Dynamics
495
13
501
Conclusions
545
Conclusions
580
14
615
Conclusions
618
Research Strategies and Examples
623
15
629

5
172
Conclusions
191
6
229
Conclusions
251
Genetic Diseases
257
Symptoms Leading to the Detection of Enzyme Defects Clinical Diagnosis
263
Prion Diseases
352
8
361
Conclusions
380
Do Thyroid Autoantibodies and Autoimmune Disease Also Enhance
393
10
402
Somatic Mutation Cancer and Aging
431
Conclusions
454
11
464
16
693
Differences Between Populations
705
18
706
Genetic Counseling and Prenatal Diagnosis Human Genome
711
Genetic Manipulations and the Biological Future
733
Conclusions
747
Data Bases and Expert Systems
757
Heritability Estimates from Twin Data
769
Genetic Counseling
775
Programs and Examples
783
Standardized Nomenclature for Human Genes
793
Index
807
Página de créditos

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Sobre el autor (1997)

Arno Gunther Motulsky was born in Fischhausen, Germany on July 5, 1923. In 1939, he was one of more than 900 Jewish refugees aboard the German liner St. Louis who were turned away from Cuba and the United States. Before returning to Germany, four countries agreed to take one-fourth of the passengers. His family was assigned to Belgium. On May 10, 1940, the Germans invaded Belgium. Even though the family had just received United States visas, they were unable to leave. Motulsky was sent to an internment camp in France. In June 1941, he left France and traveled through Spain to Portugal, where he boarded a ship to the United States. In 1942, he passed the high school equivalency tests in Chicago. He worked and began taking college courses at Central Y.M.C.A. College. In 1943, he had been accepted to medical school at the University of Illinois at Chicago. However, he was drafted and the Army sent him to Yale University to finish his premedical courses. He returned to the University of Illinois for medical school, entering as a private first class. He graduated in 1947 and took further training in internal medicine and hematology. In 1951, he was called back into the Army and assigned to Walter Reed Army Medical Center in Washington, where he studied inherited blood disorders. He was discharged in 1953. After being discharged, he became an instructor at the University of Washington's new medical school in Seattle. He taught internal medicine and hematology. He was the founder of medical genetics and pharmacogenetics. In 1957, he started one of the first divisions of medical genetics in the United States. He was the author of more than 400 scientific articles. He and Friedrich Vogel wrote the textbook, Human Genetics: Problems and Approaches, in 1979. Motulsky died on January 17, 2018 at the age of 94.

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