Pharmaceutical Gene Delivery Systems

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Alain Rolland
CRC Press, 11 abr. 2003 - 456 páginas
This volume examines the advantages and limitations of the major gene delivery systems and offers guidelines to select the most appropriate viral or synthetic delivery system for specific therapeutic applications. It discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancerous, cardiovascula
 

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Índice

Chapter 1 Introduction to Gene Therapy and Guidelines to Pharmaceutical Development
1
Chapter 2 Sustaining Transgene Expression In Vivo
17
Regulated Gene Expression
47
Chapter 4 Mechanisms for Cationic Lipids in Gene Transfer
79
Chapter 5 PolymerBased Gene Delivery Systems
109
Chapter 6 Chimeric Gene Delivery Systems
137
Chapter 7 Adenoviral Vectors for Gene Delivery
149
AdenoAssociated Virus
183
A Review
245
Chapter 11 Nonviral Approaches for Cancer Gene Therapy
279
Chapter 12 Replicating Adenoviral Vectors for Cancer Therapy
321
Chapter 13 Cardiovascular Gene Therapy
345
Chapter 14 Pulmonary Gene Therapy
363
Chapter 15 Artificial Chromosomes
397
Index
415
Back Cover
425

Chapter 9 Retrovectors Go Forward
215

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