Pharmaceutical Gene Delivery SystemsThis volume examines the advantages and limitations of the major gene delivery systems and offers guidelines to select the most appropriate viral or synthetic delivery system for specific therapeutic applications. It discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancerous, cardiovascula |
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Índice
Chapter 1 Introduction to Gene Therapy and Guidelines to Pharmaceutical Development | 1 |
Chapter 2 Sustaining Transgene Expression In Vivo | 17 |
Regulated Gene Expression | 47 |
Chapter 4 Mechanisms for Cationic Lipids in Gene Transfer | 79 |
Chapter 5 PolymerBased Gene Delivery Systems | 109 |
Chapter 6 Chimeric Gene Delivery Systems | 137 |
Chapter 7 Adenoviral Vectors for Gene Delivery | 149 |
AdenoAssociated Virus | 183 |
A Review | 245 |
Chapter 11 Nonviral Approaches for Cancer Gene Therapy | 279 |
Chapter 12 Replicating Adenoviral Vectors for Cancer Therapy | 321 |
Chapter 13 Cardiovascular Gene Therapy | 345 |
Chapter 14 Pulmonary Gene Therapy | 363 |
Chapter 15 Artificial Chromosomes | 397 |
| 415 | |
Back Cover | 425 |
Otras ediciones - Ver todo
Términos y frases comunes
AAV vectors Acad Sci USA activity adeno-associated virus adenoviral vectors adenovirus adenovirus-mediated administration airway antibody antigen binding Biol cancer cells cationic lipid cell lines cellular CFTR clinical trials complexes cystic fibrosis cytokines disease dose Drug effects efficiency electroporation encoding endosomal endothelial enhanced factor IX fdAd function gene delivery gene expression gene gun Gene Ther 1999 Gene Ther 2000 gene therapy gene transfer genetic genome growth factor Hum Gene Ther human immune response inducible inhibition injection intravenous levels ligand lipid lipoplex liposomes liver lung mediated membrane mice mifepristone mouse murine muscle Natl Acad Sci nonviral vectors nuclear packaging particles patients plasmid plasmid DNA polylysine Proc Natl Acad production promoter protein receptor recombinant regulator replication retroviral vectors sequence studies target therapeutic tion tissue toxicity transcription transduction transfection transgene transgene expression tumor tumor cells uptake vascular viral vectors Virol viruses vitro vivo gene Wilson JM
Referencias a este libro
Liposome Technology: Liposome Preparation and Related Techniques Gregory Gregoriadis Vista previa restringida - 2016 |
Información bibliográfica
| Título | Pharmaceutical Gene Delivery Systems Drugs and the Pharmaceutical Sciences |
| Editor | Alain Rolland |
| Editor | CRC Press, 2003 |
| ISBN | 0203912330, 9780203912331 |
| N.º de páginas | 456 páginas |
| Exportar cita | BiBTeX EndNote RefMan |