Pharmaceutical Gene Delivery SystemsAlain Rolland CRC Press, 11 abr 2003 - 456 páginas This volume examines the advantages and limitations of the major gene delivery systems and offers guidelines to select the most appropriate viral or synthetic delivery system for specific therapeutic applications. It discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancerous, cardiovascula |
Índice
Chapter 1 Introduction to Gene Therapy and Guidelines to Pharmaceutical Development | 1 |
Chapter 2 Sustaining Transgene Expression In Vivo | 17 |
Regulated Gene Expression | 47 |
Chapter 4 Mechanisms for Cationic Lipids in Gene Transfer | 79 |
Chapter 5 PolymerBased Gene Delivery Systems | 109 |
Chapter 6 Chimeric Gene Delivery Systems | 137 |
Chapter 7 Adenoviral Vectors for Gene Delivery | 149 |
AdenoAssociated Virus | 183 |
A Review | 245 |
Chapter 11 Nonviral Approaches for Cancer Gene Therapy | 279 |
Chapter 12 Replicating Adenoviral Vectors for Cancer Therapy | 321 |
Chapter 13 Cardiovascular Gene Therapy | 345 |
Chapter 14 Pulmonary Gene Therapy | 363 |
Chapter 15 Artificial Chromosomes | 397 |
| 415 | |
Back Cover | 425 |
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Términos y frases comunes
AAV vectors Acad Sci USA achieved activity addition adenovirus administration animals antibody application approach binding cancer cationic lipid cell lines cellular chromosomes complexes containing cytoplasm delivered demonstrated detected direct disease dose Drug edited effects efficiency enhanced et al factor function gene delivery gene expression Gene Ther 1999 gene therapy gene transfer genetic genome growth Hum Gene Ther human immune response improved increase inducible inhibition injection integration interaction levels limited liposomes liver lung mechanism mediated methods mice mouse muscle Natl Acad Sci normal nuclear observed packaging particles patients plasmid potential Proc Natl Acad production promoter protein receptor recombinant reduced region regulator replication reported retroviral sequence showed shown specific strategies studies surface target therapeutic tion tissue toxicity transcription transfection transgene expression treatment tumor vectors viral Virol virus vitro vivo
Referencias a este libro
Gene Therapy and Gene Delivery Systems David V. Schaffer,Weichang Zhou Vista previa restringida - 2005 |
Liposome Technology: Liposome Preparation and Related Techniques Gregory Gregoriadis Vista previa restringida - 2016 |