Cancer of the Esophagus: Approaches to the EtiologyCambridge University Press, 10 jun 1993 - 282 páginas The book deals briefly with the normal structure, functioning and biochemistry of the esophagus and with the histological and genetic changes accompanying the development of esophageal cancer in humans and animals. Factors implicated in causing esophageal cancer are described in relation to its very dramatic epidemiology. Thus dietary deficiencies and consumption of foods contaminated by Fusaria mycotoxins are discussed in connection with the extremely high incidence of the disease in certain sharply demarcated regions in China and South Africa, and alcohol and tobacco use are discussed in relation to the epidemiology in Europe and USA. Other hazards mentioned include opium in Iran, betel nut in Asia and bracken in Japan. The sole group of chemicals known to be very potent esophageal carcinogens in animal experiments, the nitrosamines, are described especially in terms of the widespread human exposure. |
Índice
Biology of the esophagus | 4 |
Esophageal carcinogenesis | 22 |
Epidemiology | 47 |
Mechanism of carcinogenicity of Nnitrosamines | 84 |
In vivo formation of Nnitroso compounds from | 96 |
Risk assessment | 104 |
Alcoholic beverages and tobacco | 117 |
Effect of alcohols on DNA alkylation by nitrosamines | 148 |
Effect of alcohol consumption on nutrition | 154 |
phenolics tannins | 170 |
opium silica bracken dihydrosafrole | 196 |
Molds and mycotoxins | 221 |
micronutrients fresh plant food | 247 |
Possible mechanisms involved in carcinogenesis | 272 |
280 | |
Otras ediciones - Ver todo
Cancer of the Esophagus: Approaches to the Etiology Valda M. Craddock No hay ninguna vista previa disponible - 2009 |
Cancer of the Esophagus: Approaches to the Etiology Valda M. Craddock No hay ninguna vista previa disponible - 1993 |
Términos y frases comunes
acid adenocarcinoma alcohol consumption alcoholic beverages alimentary alkylation amines animals areas associated with esophageal Barrett's esophagus basal cells beer betel Biochem bracken Cancer Inst cancer rate Cancer Res carcinogenesis carcinogenic carcinoma cause of esophageal cell replication chemicals China chronic concentrations consumed contain Craddock detected diet dietary dihydrosafrole disease drink effect of ethanol enzymes Epidemiology esophageal cancer esophageal carcinogen esophageal carcinoma especially ethanol evidence exposure forestomach Fusarium fusel alcohols gastric hamsters hazard high incidence higher alcohols human hyperplasia incidence of esophageal increase induced infected inhibition intake Iran keratin lesions levels Linxian liver maize metabolism mice micronutrients microsomes mucosa mutagenic mycotoxins N-nitroso compounds Natl NDMA nitrite nitrosamines nitrosation NMBZA Nutr occur opium oral organs papillomas phenolics plants protein quercetin rate of esophageal regions result riboflavin safrole silica smoking squamous cell stomach studies T-2 toxin tannins tobacco toxic treatment trichothecenes tumors Tuyns vegetables vitamin wine zinc deficiency