New Research on DNA RepairNova Publishers, 2007 - 393 páginas As a major defence against environmental damage to cells DNA repair is present in all organisms including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA damage and genomic instability. Abnormalities in these processes have been implicated in cancer and ageing. This book presents leading-edge research from around the world in this frontal field. |
Índice
| 1 | |
DNA Repair and Lung Cancer Chikako Kiyohara1 Koichi Takayama2 and Yoichi Nakanishi2 | 39 |
Comet Assay as a Tool to Evaluate DNA Repair Activity and Inhibition Dellia Cavallo and Cinzia Lucia Ursini | 85 |
Dietary Compounds that Enhance DNA Repair and their Relevance to Cancer and Aging Harris Bernstein13 Cheray CrowleySkillicorn1 Carol Bernst... | 99 |
Gene Prophylaxis of Endogenous DNA Damage Guido Frosina | 115 |
Translesion DNA SynthesisA Fundamental DNA Damage Tolerance Mechanism Errol C Friedberg and Lisa D McDaniel | 167 |
LongTerm RNA Interference Toward a Set of Isogeneic Human Cells Deficient in DNA Repair Genes DSF Biard and JF Angulo | 191 |
Peculiarities of Base Excision Repair in Loach Embryogenesis Natalia Sharova | 219 |
Roles of Plant Transcription Factor IIH subunit homologs in nucleotide Excision Repair and Transcription Desina M Grice1 Megan J Osmond Micha... | 251 |
Repair of RadiationInduced DNA DoubleStrand Breaks in Human Cells History Progress and Controversies Aurellie Joubert12 and Nicolas Foray1 | 273 |
DNA DoubleStrand Breaks Repair Pathways in the Framework of Chromatin Tom C Karagiannis12 and Assam ElOsta3 | 295 |
Role of p53 in the Repair of Ionizing RadiationInduced DNA Damage David Murray and Razmik Mirzayans | 325 |
| 375 | |
Términos y frases comunes
acid activity agents antisense assay associated base binding Biol carcinogenesis Caucasian cell lines cellular Chem chromatin chromosome complex containing defective DNA damage DNA glycosylase DNA polymerase DNA repair doses double-strand breaks DSB repair effects efficiency endogenous enzyme et al excision repair exposure expression factors Figure function gene genetic genome genotype glycosylase homologous human human cells important increased indicate induced inhibition initial interaction involved kinase lead lesions levels lung cancer major mechanisms mice molecular mutations Nature NHEJ normal nucleotide observed oxidative pathway polymorphism protection protein radiation radiosensitivity recent recombination reduced regulation removal repair pathway replication reported response risk RNAi role sensitivity sequence showed shown single specific strand structure studies substrates suggested synthesis therapy transcription tumor types vectors vitro vivo XRCC1 yeast
Pasajes populares
Página 363 - KASTAN, MB, ZHAN, Q., EL-DEIRY, WS, CARRIER, F., JACKS, T., WALSH, WV, PLUNKETT, BS, VOGELSTEIN, B. and FORNACE. AJ, JR. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia.
Página 363 - Participation of p53 protein in the cellular response to DNA damage.
Página 26 - Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.