Focus on Genome ResearchNova Publishers, 2004 - 424 páginas The genomic approach of technology development and large-scale generation of community resource data sets has introduced an important new dimension in biological and biomedical research. Interwoven advances in genetics, comparative genomics, high throughput biochemistry and bioinformatics are combining to attack basic understanding of human life and disease and to develop strategies to combat disease. Genomic Research began with The Human Genome Project (HGP), the international research effort that determined the DNA sequence of the entire human genome, completed in April 2003. The HGP also included efforts to characterize and sequence the entire genomes of several other organisms, many of which are used extensively in biological research. Identification of the sequence or function of genes in a model organism is an important approach to finding and elucidating the function of human genes. Integral to the HGP are similar efforts to understand the genomes of various organisms commonly used in biomedical research, such as mice, fruit flies and roundworms. Such organisms are called "model organisms," because they can often serve as research models for how the human organism behaves. This new book brings together leading research from throughout the world in this cutting-edge field. |
Índice
1 | |
Molecular Diversity of Porcine and Simian Picornavirus | 39 |
Molecular Characterization of Dengue Virus Studies of Brazilian Strains | 81 |
Genomics and Evolution of Metazoan Ga Proteins | 133 |
InterProPrediction of Protein Families Domains and Functional Sites | 158 |
Plant BAC Libraries as Tools for Molecular Cytogenetics | 194 |
Automated Sample Preparation of Nucleic Acids Development and Application using Magnetic Particles | 210 |
Evidence from Comparative Genomics for a Sexual Cycle in the Asexual Fungal Pathogen Aspergillus Fumigatus | 240 |
Egg Fertilizome From Transmembrane Signaling to Translational Control of Gene Expression in the Initiation of Development | 262 |
Organization and Evolution of 5S Ribosomal DNA in the Fish Genome | 324 |
Targeted Modification of Mammalian Genomes | 354 |
TGFB and Matrix Metalloproteinases | 386 |
Index | 406 |
Términos y frases comunes
AAA AUU UUC Acids Res adenylate residues alignment alpha subunit amino acid analysis AUG GCA UGU binding Biol cDNA cell lines cellular chromosome clones conserved containing database dengue hemorrhagic fever dengue virus DENV detected domain egg activation egg fertilization encoding enteroviruses Figure FISH fumigatus function G protein GCA UGU UUG genetic genome genotype HAV genome homologous recombination identified infection integration interaction InterPro interstitial negative isolated kinase Kusov loxP magnetic particles mammalian membrane Miagostovich molecular motif mouse mRNAs mutation nucleic acid nucleotide nucleotide sequence oocytes pheromone phosphorylation phylogenetic picornaviruses plasmid poly(A polyadenylation polymerase porcine protein families protein sequences proteomics pseudogene rDNA receptor recombinase replication replicon rRNA rRNA genes selection marker serotypes SFKs signal similarity species sperm sperm-egg strains strategy structure Swiss-Prot tail target teschovirus transcription transfection transgene translation tyrosine UGU UUG AAA UUG AAA AUU vector viral Virol viruses vitro xSrc