Programmed Cell DeathCRC Press, 8 dic 1993 - 331 páginas Although general morphological features have been used to consistently identify the changes in cell ultrastructure occurring during apoptosis, as distinct from necrosis, important advances have been achieved more recently in the investigation of the cellular and molecular aspects of this process. This book brings together the latest international research on the complex subject of programmed cell death, and covers such areas as the biochemical mechanisms, introduction of DNA fragmentation, enetic regulation, and the importance of apoptosis in the immune system, particularly during T-cell development, and in cancer. The comparison of a number of common signal transduction pathways with those involved in cell growth highlights an important relationship between apoptosis and the control of cell proliferation. |
Índice
Definition of Apoptosis and Overview | 1 |
Signal Transduction in Thymocyte Apoptosis | 19 |
Glucocorticoid | 31 |
Protein Modification in Apoptosis | 45 |
Relationship Between Apoptosis and the Cell Cycle | 59 |
Intracellular Zinc and the Regulation of Apoptosis | 73 |
Induction of Apoptosis by the Immunomodulating | 87 |
GlucocorticoidInduced Programmed Cell Death | 99 |
The Role of Tumour Suppressor Genes in Apoptosis | 187 |
Altered Gene Expression During Apoptosis | 203 |
The Role of Apoptosis in the Regulation of | 219 |
At the Crossroad | 229 |
Apoptosis in the Target Organ of | 235 |
Peptide EpitopeInduced Apoptosis of Human | 245 |
Apoptosis in Irradiated Murine Tumours and Human | 259 |
AntiCancer Drugs and Apoptosis | 269 |
Evidence for the Role of an EndoExonuclease in | 111 |
Critical Changes in Apoptosis in Thymocytes | 123 |
Regulation of Programmed Cell Death | 145 |
Macromolecular Synthesis cmyc and Apoptosis | 153 |
The bcl2 Oncogene Regulates Lymphocyte | 167 |
Bcl2 Expression in the Prostate and its Association | 179 |
Apoptosis Resulting from AntiCancer Agent Activity | 279 |
HyperthermiaInduced Apoptosis | 297 |
Tubulin in Apoptotic Cells | 315 |
325 | |
Términos y frases comunes
agents antibody antigen apoptosis apoptosis induced apoptotic apoptotic bodies apoptotic cells biochemical Biological Chemistry Biology c-myc Ca2+ calcium Cancer Research cDNA cell cycle cell lines cellular chromatin clones Cohen concentrations cycloheximide cytotoxic dexamethasone DNA cleavage DNA fragmentation doses drug endo-exonuclease endonuclease Figure gene expression gliotoxin glucocorticoid receptor glucocorticoid-induced growth factor Harmon human hybridomas hyperthermia immature thymocytes increase induce apoptosis induction of apoptosis inhibition inhibitor internucleosomal DNA intracellular involved irradiation Journal of Biological Journal of Immunology Kerr levels lymphocytes lymphoid lymphoma McConkey mechanism mediated membrane mice molecular morphological mRNA murine necrosis normal novobiocin nuclear nuclei observed okadaic acid oncogene pathway perforin phorbol esters phosphorylation programmed cell death proliferation prostate protein kinase protein synthesis radiation regulation response role signal specific stimulation studies T-cell hybridomas target cell thymocyte apoptosis thymocytes thymus tissues transgenic treatment tubulin tumour tyrosine undergo apoptosis vitro vivo Wyllie zinc
Pasajes populares
Página 323 - Kerr, JFR, Wyllie, AH, and Currie, AR (1972) Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics.
Página 294 - Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note. Cancer Res. 49, 5870-5878.