Molecular Pathology of Early Cancer

Portada
Sudhir Srivastava, Donald Earl Henson, Adi F. Gazdar
IOS Press, 1999 - 481 páginas
This book describes the principles and the application of the existing molecular methodology for the detection of early cancer. Discussion focuses on the molecular changes characterizing preneoplastic lesions; molecular targets for early detection; validation of molecular targets; and new diagnostic technology for early detection. The advantages of molecular detection over current methods are examined, as well as the importance of identifying and characterizing preneoplastic lesions. In addition to the uses of highly specific molecular probes to detect early cancer, this book demonstrates the many ways in which molecular markers serve oncology. While meeting pressing needs in the practice of medicine, molecular detection of early cancer scientifically necessitates a confrontation with the biology of cancer, such as the genetic determinants of progression, regression, dormancy, and invasion. This work not only discusses the diagnostic value of these molecular methods but views their practical benefits against a background of conventional morphology.
 

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Índice

Pathobiology of Incipient Neoplasia
3
Early Events During Neoplastic Transformation of Human Cells In Vitro
27
Molecular Pathology and Biomarkers of Bladder Cancer
53
Biologic Characteristics of Premalignant Breast Disease
79
The Molecular Pathogenesis of Cervical Cancer The Role of Human Papillomaviruses
97
Central Nervous System
113
W E Grizzle D Shibata U Manne R B Myers and A R Frost
135
Overview of Alternative Genetic Pathways in Colorectal Carcinogenesis
171
Ovarian and Endometrial Cancer Molecular Pathology
277
Pathology and Molecular Biology of Early Prostate Cancer
301
The Molecular Phenotype of the Malignant Prostate
321
Stomach Genetic and Epigenetic Alterations of Preneoplastic and Neoplastic Lesions
341
The Cancer Genome Anatomy Project Building a New Information and Technology
365
Molecular Cytogenetic Evidence for Multistep Tumorigenesis Implications for Risk
385
Microsatellite Instability
405
Telomerase and Cancer
425

Molecular Pathology of Cutaneous Melanoma
207
Pathogenesis of Early Leukemia and Lymphoma
233
Liver Cancer
255
Laser Capture Microdissection Applications in Early Cancer Molecular Research
447
Subject Index
473
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Referencias a este libro

Cancer
Robert A. Meyers
Vista previa restringida - 2007

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