Molecular Pathology of Early CancerSudhir Srivastava, Donald Earl Henson, Adi F. Gazdar IOS Press, 1999 - 481 páginas This book describes the principles and the application of the existing molecular methodology for the detection of early cancer. Discussion focuses on the molecular changes characterizing preneoplastic lesions; molecular targets for early detection; validation of molecular targets; and new diagnostic technology for early detection. The advantages of molecular detection over current methods are examined, as well as the importance of identifying and characterizing preneoplastic lesions. In addition to the uses of highly specific molecular probes to detect early cancer, this book demonstrates the many ways in which molecular markers serve oncology. While meeting pressing needs in the practice of medicine, molecular detection of early cancer scientifically necessitates a confrontation with the biology of cancer, such as the genetic determinants of progression, regression, dormancy, and invasion. This work not only discusses the diagnostic value of these molecular methods but views their practical benefits against a background of conventional morphology. |
Índice
Pathobiology of Incipient Neoplasia | 3 |
Early Events During Neoplastic Transformation of Human Cells In Vitro | 27 |
Molecular Pathology and Biomarkers of Bladder Cancer | 53 |
Biologic Characteristics of Premalignant Breast Disease | 79 |
The Molecular Pathogenesis of Cervical Cancer The Role of Human Papillomaviruses | 97 |
Central Nervous System | 113 |
Molecular and Histopathologic Changes in the Development of Colorectal Neoplasia | 135 |
Overview of Alternative Genetic Pathways in Colorectal Carcinogenesis | 171 |
Ovarian and Endometrial Cancer Molecular Pathology | 277 |
Pathology and Molecular Biology of Early Prostate Cancer | 301 |
The Molecular Phenotype of the Malignant Prostate | 321 |
Stomach Genetic and Epigenetic Alterations of Preneoplastic and Neoplastic Lesions | 341 |
The Cancer Genome Anatomy Project Building a New Information and Technology | 365 |
Molecular Cytogenetic Evidence for Multistep Tumorigenesis Implications for Risk | 385 |
Microsatellite Instability | 405 |
Telomerase and Cancer | 425 |
Molecular Changes in the Multistage Pathogenesis of Head and Neck Cancer | 189 |
Molecular Pathology of Cutaneous Melanoma | 207 |
Pathogenesis of Early Leukemia and Lymphoma | 233 |
Liver Cancer | 255 |
Laser Capture Microdissection Applications in Early Cancer Molecular Research | 447 |
473 | |
Términos y frases comunes
abnormalities Acad Sci USA adenocarcinoma adenomas allelic allelic loss amplification analysis aneuploidy antigen associated Barrett's esophagus biomarkers biopsy bladder cancer breast cancer Cancer Res 54 carcinogenesis carcinogenic cell cycle cell lines cellular chromosome Clin clinical clonal colon colorectal cancer correlation CRCs cyclin cytogenetic deletions differentiated disease ductal dysplasia epithelial epithelium expression frequently gastric carcinomas genomic instability germline grade growth factor histologic HNPCC human papillomavirus hyperplasia identified immortalization inactivation invasive K-ras kinase lesions leukemia loci locus loss of heterozygosity lung cancer malignant markers melanoma metastatic microsatellite instability mismatch repair molecular Natl Acad Sci neoplasia neoplastic normal oncogene Oncol ovarian cancer overexpression p53 gene p53 mutations pancreatic Pathol Pathology pathway patients phenotype ploidy premalignant primary Proc Natl Acad prognostic progression proliferation prostate cancer protein receptor region risk sequences specific specimens studies syndrome telomerase telomerase activity telomere tissue tumor cells tumor suppressor gene tumorigenesis Urol