Asthma: Causes and Mechanisms
CRC Press, 27 abr. 1999 - 256 páginas
Asthma is a disease which, beginning in the 1980s, increased in the United States and other countries in both its prevalence and mortality. According to reports by the Center for Disease Control, the number of people with asthma increased by 42% in the last decade, with children, ethnic minorities and the urban poor being most at risk.
Timely research on the causes and mechanisms behind the dramatic increase of asthma in the United States and other nations-to epidemic proportions-is presented in this volume.
Investigators heading up eight research groups in asthma and/or allergy present their most recent findings, funded by the Center for Indoor Air Research. In addition to the work underway and discussions/suggestions on present research problems, ASTHMA: Causes and Mechanisms of an Epidemic Inflammatory Disease provides a chapter on the causes of asthma-and the reasons for its recent spread, so hotly discussed in the current literature.
Researchers in the fields of asthma and allergy, health care providers, and others who follow research in either of these two developing areas will benefit from this book. The book is written at the level of one investigator to another.
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The Rising Prevalence and Severity of Asthma
Viral Modulation of Airway Inflammation
The Risk of Developing Asthma During Childhood
Loss of Airway M Muscarinic Receptor Function
Role of CD4+ T Cells in the Development of
Modified Recombinant Allergens for Immunotherapy
The Effects of Environmental Tobacco Smoke on
The Effects of
The Role of Genetics and Indoor Allergen Exposure
acetylcholine aerosol airway hyperresponsiveness airway inflammation airway obstruction airway responses allergen allergic asthma allergic disease Allergy Clin Immunol animals antigen antigen challenge associated asthmatic subjects atopic atopy bronchial bronchoalveolar lavage bronchoconstriction CD4+ T cells chromosome cockroach allergen cockroach-sensitive cytokine cytokine production dose dust mite allergen effect endotoxin enhance environmental eosinophil epithelial cells exacerbations expression FEV1 Fryer gene genetic guinea pigs histamine house dust mite human hyperreactivity IgE antibody immune response immunotherapy increase in asthma indoor allergens induced inflammation inflammatory response inhalant allergens inhibits interleukin Jacoby Kang linkage lymphocytes M2 receptor major basic protein markers mast cells mediators mice muscarinic receptors nasal neutrophils ozone patients peptides phenotype Platts-Mills TAE pulmonary reactivity receptor function Resp Crit Respir respiratory tract rhinitis rhinovirus rhinovirus infection risk factor role sensitization serum IgE skin test specific Sporik stimulation studies symptoms tobacco smoke viral infections virus vitro vivo wheezing