Molecular Biology of the Lung: Emphysema and Infection

acid activity addition aeruginosa alveolar animals antitrypsin associated bacterial binding Biol Chem caused cells CFTR changes Clin clinical collagen complex components contains culture cystic fibrosis cytokines deficiency demonstrated detected diagnosis disease effect elastase elastin element emphysema enhancer enzyme epithelial cells expression factor Figure function gene genetic genome granules Haemophilus influenzae host human identified Immun important increase indicated induced infection inhibits initiation interaction Invest involved leukocyte levels liver lung macrophages major mechanism mediated membrane mice models mouse mRNA mutation Nature neutrophil neutrophil elastase normal occurs patients pneumonia position present production promoter protease protein proteinase inhibitor pulmonary recently receptor region regulation regulatory reported Respir respiratory response role secretion secretory sequence serine proteinases serum showed shown similar SLPI specific strains structure studies suggested surface tissue transcription transcription factor transgenic tuberculosis vitro