Dermal Absorption and Toxicity AssessmentMichael S. Roberts CRC Press, 14 dic 2007 - 704 páginas The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab |
Índice
| 1 | |
Chapter 2 Animal Skin Morphology and Dermal Absorption | 17 |
Chapter 3 The Physical Structure of the Skin Barrier | 37 |
Chapter 4 Morphology of Epidermal Lipids | 69 |
Chapter 5 Stratum Corneum as a Biosensor | 79 |
Chapter 6 Cutaneous Metabolism | 89 |
Chapter 7 Formulation Issues | 117 |
Chapter 8 Interpretation of In Vitro Skin Absorption Studies of Lipophilic Chemicals | 135 |
Chapter 23 Systemic Toxicity Caused by Absorption of Drugs and Chemicals Through Skin | 405 |
Chapter 24 Solvent and Vehicle Effects on the Skin | 433 |
Chapter 25 United States Environmental Protection Agency Perspectives on Skin Absorption and Exposure | 449 |
Some Australian Regulatory Considerations | 459 |
Chapter 27 International Perspectives in Dermal Absorption | 471 |
Chapter 28 StructureActivity Relationships and Prediction of Photoallergic and Phototoxic Potential | 483 |
Chapter 29 Potential Regulatory Use of QSARs to Develop Dermal Irritation and Corrosion Assessment Strategies | 495 |
Chapter 30 Development of QSARs for Dermal Irritation and Corrosion Assessment Using European Union New Chemicals Notification Data | 507 |
Chapter 9 Use of Skin Equivalents for Dermal Absorption and Toxicity | 141 |
Chapter 10 Skin Absorption as Studied by Spectroscopic Methods | 161 |
Chapter 11 Physiologically Based Pharmacokinetics and Pharmacodynamics of Skin | 179 |
Chapter 12 Beyond Stratum Corneum | 209 |
Chapter 13 Biophysical Models for Skin Transport and Absorption | 251 |
Chapter 14 Mathematical Models for Different Exposure Conditions | 271 |
Chapter 15 Modeling Skin Permeability in Risk Assessment | 287 |
Chapter 16 In VitroIn Vivo Correlations in Transdermal Drug Delivery | 299 |
Chapter 17 Estimation of Subsequent Systemic ExposurePhysiological Models | 309 |
Predictions Based on In Vivo Factors | 323 |
Chapter 19 Quantitative StructureActivity Relationships for Skin Corrosivity and Sensitization | 339 |
Chapter 20 Allergic Contact Dermatitis | 359 |
Chapter 21 Irritancy of Topical Chemicals in Transdermal Drug Delivery Systems | 371 |
Phototoxicity and Photoallergy | 391 |
Chapter 31 Regulatory Assessment of Skin Sensitization | 523 |
Chapter 32 Assessment of Topical Bioequivalence Using Microdialysis and Other Techniques | 537 |
Chapter 33 An Industry Perspective of Topical Dermal Bioequivalence | 549 |
Chapter 34 Dermal Absorption of Chemical Contaminants from Soil | 563 |
Chapter 35 Percutaneous Absorption of Pesticides | 575 |
Percutaneous Absorption of Water Contaminants | 593 |
Chapter 37 Percutaneous Absorption of Prodrugs and Soft Drugs | 605 |
Chapter 38 Skin Penetration of Cosmetic Ingredients and Contaminants | 623 |
Chapter 39 Percutaneous Absorption of Hair Dyes | 635 |
Chapter 40 Dermal Absorption of Fragrance Materials | 651 |
| 665 | |
Back cover | 679 |
Otras ediciones - Ver todo
Dermal Absorption and Toxicity Assessment, Second Edition Michael S. Roberts,Kenneth A. Walters Vista de fragmentos - 2008 |
Dermal Absorption and Toxicity Assessment S. Roberts Michael No hay ninguna vista previa disponible - 1998 |
Términos y frases comunes
absorbed acid activity amount animal application approach assessment barrier blood body cause cell chemical coefficient compared compounds concentration containing cosmetic cutaneous delivery depends dermal absorption dermis described determined developed diffusion distribution dose drug edited effect enhancers epidermis equation estimate et al evaluation exposure expression factors FIGURE flux formulations function hair human skin important increased Invest Dermatol irritation keratinocytes layers levels limited lipid lipophilic Maibach material measured membrane methods obtained organic partition patch penetration percutaneous absorption permeability permeation Pharm Pharmacol phase potential prediction properties reactions receptor relative reported response risk assessment Roberts sensitization showed similar soil solubility solute specific stratum corneum structure studies substances surface systemic Table tissue topical toxicity Toxicol transdermal transport values vehicle viable vitro vivo
Referencias a este libro
Skin, Hair, and Nails: Structure and Function Bo Forslind,Magnus Lindberg No hay ninguna vista previa disponible - 2003 |