Tumor Suppressor Genes: Volume 1: Pathways and Isolation StrategiesWafik S. El-Deiry Springer Science & Business Media, 3 feb 2008 - 520 páginas It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control. |
Índice
3 | |
9 | |
Somatic Cell Knockouts of Tumor Suppressor Genes | 15 |
Inadequate Caretaker Gene Function | 16 |
The APC Tumor Suppressor Pathway | 21 |
Functional Analysis of Tumor Suppressor Genes in Mice | 23 |
Blocking Survivin to Kill Cancer Cells | 34 |
Hereditary Breast and Ovarian Cancer Genes | 41 |
The INK4aARF Locus and Human Cancer | 197 |
Progression Model of Prostate Cancer | 217 |
Teresa Acosta Almeida and Nickolas Papadopoulos 14 Neurofibromatosis Type 1 | 223 |
Using Saccharomyces cerevisiae | 226 |
Tumor Suppressor Gene Therapy | 232 |
JEREMY JUANG Department of Pathology The Johns Hopkins Medical Institutions | 233 |
The Regulation of Tumor Suppressor Genes by Oncogenes | 275 |
Determination of Cancer Allelotype | 297 |
Grady and Sanford D Markowitz 5 Patched Hedgehog and Skin Cancer | 59 |
Anthony G Quinn and Ervin Epstein Jr 6 Tumor Suppressor Genes in Lung Cancer | 85 |
Arvind K Virmani and Adi F Gazdar 7 TP53 hChk2 and the LiFraumeni Syndrome | 97 |
DeWeese and William G Nelson | 110 |
Jenny Varley 8 Genetic Alterations in Esophageal Cancer | 117 |
PTEN and Cancer | 147 |
VHL and Kidney Cancer | 167 |
p16INK4A and Familial Melanoma | 185 |
MICHAEL BIRRER Biomarkers Branch Division of Clinical Sciences National | 187 |
KERI FAIR Section of HematologyOncology University of Chicago Chicago IL | 306 |
HUA QIAN Department of Surgery Shanghai Second Medical University Shangai | 310 |
Characterization of Translocations in Human Cancer | 337 |
21 | 344 |
Hybrid Capture of Putative Tumor Suppressor Genes | 371 |
Representational Difference Analysis of Gene Expression | 387 |
LE BEAU Section of HematologyOncology University of Chicago | 434 |
Crosslinking Subtractive Hybridization | 439 |
Otras ediciones - Ver todo
Tumor Suppressor Genes: Volume 1: Pathways and Isolation Strategies Wafik S. El-Deiry No hay ninguna vista previa disponible - 2003 |
Tumor Suppressor Genes: Volume 1: Pathways and Isolation Strategies Wafik S. El-Deiry No hay ninguna vista previa disponible - 2003 |
Tumor Suppressor Genes: Volume 1: Pathways and Isolation Strategies Wafik S. El-Deiry No hay ninguna vista previa disponible - 2003 |
Términos y frases comunes
Acad activity adenocarcinoma adenomatous polyposis allele allelic loss alterations analysis APC gene apoptosis associated b-catenin BCCs beta-catenin binding Biol BRCA1 BRCA1 and BRCA2 BRCA2 breast cancer cancer cells Cancer Res cDNA cell cycle cell lines chromosome cloning colon cancer colorectal cancer complex cyclin D1 deletion detected disease domain Drosophila encodes esophageal cancer exon expression families function gene product Genes Dev genetic genomic germline mutations germline TP53 mutations growth factor Hippel-Lindau homolog human identified inactivation induced inhibition inhibitor interaction kinase locus lung cancer melanoma methylation mice microsatellite mismatch repair molecular mouse mRNA multiple Natl Oncogene overexpression Pathol patients phenotype phosphatase phosphorylation Proc proliferation prostate cancer protein PTEN pVHL receptor recombination region regulation renal retinoblastoma role sequence signaling pathway somatic sporadic squamous cell carcinoma studies syndrome target TGF-b tion tissue transcription factor TSGs tumor suppressor gene tumorigenesis wild-type