Dna Repair, Genetic Instability, And CancerQingyi Wei, Lei Li, David J Chen World Scientific, 8 ene 2007 - 376 páginas This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention. |
Índice
1 | |
Chapter 2 Base Excision Repair Bo Hang | 23 |
Chapter 3 Nucleotide Excision Repair Lei Li | 65 |
Biological Functions and Molecular Mechanisms GuoMin Li | 87 |
Chapter 5 Mammalian Homologous Recombination Repair and Cancer Intervention Zhiyuan Shen and Jac A Nickoloff | 119 |
Chapter 6 Role of NonHomologous End Joining in the Repair of DNA DoubleStrand Breaks Sandeep Burma Benjamin Chen and David J Chen | 157 |
Chapter 7 A DNAdamage Response Network of Fanconi Anemia and BRCA Proteins Rong Guo and Weidong Wang | 177 |
Lesion Recognition Wei Yang | 203 |
Chapter 9 DNA Damage Tolerance and Translesion Synthesis Fang Xu Yingnian Yu and Wei Xiao | 233 |
Flap Endonuclease1 as a Paradigm Purnima Singh and Binghui Shen | 267 |
Application in Cancer Research Maxwell P Lee | 301 |
Chapter 12 Molecular Epidemiology of DNA Repair and Cancer Susceptibility A Review of PopulationBased Studies Zhibin Hu LiE Wang and Qing... | 315 |
345 | |
Otras ediciones - Ver todo
DNA Repair, Genetic Instability, and Cancer Qingyi Wei,Dr. Lei Li,Dr. David Chen Vista previa restringida - 2007 |
Términos y frases comunes
Acad Sci USA activity adducts allelic AP endonuclease APE1 associated base excision repair base pairs binding biochemical Biol Chem BRCA1 BRCA2 bypass cancer cell cycle cell cycle checkpoints cellular checkpoint Chk1 Chk2 chromatin chromosome coli defective DNA damage DNA damage response DNA double-strand break DNA glycosylases DNA lesions DNA polymerase DNA repair DNA replication DNA-PKcs domain EMBO enzymes eukaryotic FANCD2 FANCJ FANCM Fanconi anemia function gene expression genomic stability helicase HNPCC homologous recombination identified interactions involved kinase ligase mammalian cells mechanism methylation mice mismatch repair Mol Cell Biol molecular monoubiquitination Mutat Res MutS Natl Acad Sci NHEJ nuclear nucleotide excision repair PCNA phenotype phosphorylation Proc Natl Acad regulation repair genes repair pathways repair protein replication forks response to DNA Rev1 role sequence single-stranded SNPs specific strand structure studies substrate syndrome target template tion transcription tumor ubiquitin uracil vitro yeast