Medicinal Applications of Coordination ChemistryRoyal Society of Chemistry, 31 oct 2007 - 366 páginas Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds. This book is ideal for researchers in academia and industry and comes complete with examples of real life applications. |
Índice
CHAPTER 1 Introduction | 1 |
CHAPTER 2 The Chemistry of Metals in a Nutshell ... | 15 |
CHAPTER 3 Diagnostic Medicine | 101 |
CHAPTER 4 Therapeutic Medicine | 201 |
CHAPTER 5 Metallopharmaceuticals Design | 324 |
340 | |
344 | |
Otras ediciones - Ver todo
Medicinal Applications of Coordination Chemistry Chris J. Jones,John Thornback Vista previa restringida - 2007 |
Medicinal Applications of Coordination Chemistry Chris J. Jones,John Thornback Vista de fragmentos - 2007 |
Términos y frases comunes
acid activity adducts antibody antitumor applications aqueous behaviour bifunctional agents biological bleomycin blood bonding bone cancer carboxylate cell charge chelating chelation therapy chemical chloride cisplatin Cl Cl clinical compounds containing contrast agents covalent crystal field d-block d-block metal diagnostic dioxygen donor atoms dose drugs effect electron configuration elements energy enzyme example excretion Fe3+ Figure formation Ga3+ Gd3+ hydrogen hydrolysis imaging agents important interaction involves ionic iron kgÀ1 labelled labile lanthanide ligand ligand structure lipophilic liver magnetic metal binding metal centre metal complexes metal ion metallopharmaceuticals octahedral orbitals oxidation number oxygen platinum present proligand properties protein proton radiation radionuclide radiopharmaceutical reaction reactive redox reduced ruthenium similar solubility specific stability constants subshell substituents symmetry target TcO3+ technetium therapeutic therapy tissue toxicity tumor uptake valence shell vanadium vivo water molecule